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NCT02225041 · ClinicalTrials.gov registry record
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
A clinical trial of Intellectual Disability and Memory Disorders, sponsored by University of Pennsylvania.
- Completed
- Registry status
- 360
- Enrollment target
- 20
- Study locations
NCT02225041: Completed study of Intellectual Disability and Memory Disorders, sponsored by University of Pennsylvania.
NCT02225041 is a study of Intellectual Disability and Memory Disorders that has completed, run by University of Pennsylvania. The registered enrollment target is 360 participants, roughly in line with the 340-participant average among 26 other Intellectual Disability trials with a reported enrollment target. The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02225041, a study of Intellectual Disability and Memory Disorders, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- 360 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will test for drug- and dose-dependent relationships between sedative exposure and neurocognitive outcomes along the early developmental spectrum and will control for baseline and environmental factors, as well as the severity and course of illness. Hypotheses: 1. Greater exposure to benzodiazepines and/or ketamine will be associated with lower IQ even when controlling for severity of illness, hospital course, and baseline factors. In addition, benzodiazepines and/or ketamine will negatively affect other aspects of neurocognitive function. 2. Younger children exposed to benzodiazepines and/or ketamine will have worse neurocognitive outcomes than older children with similar sedative exposure and severity of illness.
Conditions Studied
Study Locations (20)
California
- Children's Hospital and Research Center at Oakland - Oakland
- Children's Hospital of Orange County - Orange
- Lucile Salter Packard Children's Hospital at Stanford - Palo Alto
- University of California Davis Medical Center - Sacramento
- Children's Hospital at University of California San Francisco Medical Center - San Francisco
Connecticut
- Connecticut Children's Medical Center - Hartford
- Yale-New Haven Children's Hospital - New Haven
Florida
- Holtz Children's Hospital - Miami
- Florida Hospital for Children - Orlando
Illinois
- Children's Memorial Hospital, Chicago - Chicago
- Advocate Hope Children's Hospital - Oak Lawn
Maryland
- University of Maryland Hospital for Children - Baltimore
- Johns Hopkins Children's Center - Baltimore
Missouri
- Children's Mercy Hospital, Kansas City - Kansas City
- St. Louis Children's Hospital - St Louis
Alabama
- Children's Hospital of Alabama - Birmingham
Arizona
- University Medical Center, The University of Arizona - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2014-08 |
| Est. Completion | 2018-12 |
What the finished NCT02225041 record still lists
NCT02225041 is an observational study that tracks outcomes without assigning an intervention. The registered 360 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 340-participant average among 26 other Intellectual Disability trials with a reported enrollment target.
The record links to 3 conditions, with Intellectual Disability appearing as the primary indexed condition, and to 0 interventions.
NCT02225041 names 20 study sites across 11 states, led by California, Connecticut, Florida.
Frequently Asked Questions
What is clinical trial NCT02225041 about?
NCT02225041 is a clinical study titled "Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood". The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will test for drug- and dose-dependent relationships between sedative exposure and neurocognitive outcomes along the early developmental s...
What is the current status of trial NCT02225041?
This trial is currently completed. The enrollment target is 360 participants. The study started on 2014-08. Estimated completion is 2018-12.
What conditions does trial NCT02225041 study?
This clinical trial studies the following conditions: Intellectual Disability, Memory Disorders, Perceptual Disorders.
Who is sponsoring clinical trial NCT02225041?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02225041 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Intellectual Disability
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02225041's enrollment target sits among peer trials
360 7th of 26 higher than 20 of 26 other Intellectual Disability trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Intellectual Disability trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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