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NCT02221245 · ClinicalTrials.gov registry record
Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients
A clinical trial, sponsored by University of Miami.
- Terminated
- Registry status
- 24
- Enrollment target
NCT02221245 is a clinical trial that was terminated before completion, run by University of Miami. The registered enrollment target is 24 participants.
The verdict
NCT02221245 was terminated before completion, sponsored by University of Miami.
- TERMINATED
- Registry status
- 24 participants
- Enrollment target
Study Summary
Cancer results when undifferentiated cells grow in an uncontrolled manner, crowding out normal cells, causing morbidity and ultimately mortality. the cancer stem cell theory suggests that most tumors undergo a process of differentiation through which a relatively rare cancer stem or progenitor cell (CSC) gives rise to more differentiated populations of cells (including transiently amplifying cells) comprising the bulk of the tumor. As a result of this cellular diversity, one or more cells within the tumor are likely to be resistant to therapy. Among cells resistant to a given therapy, only CSCs can repopulate the tumor. A key feature of this resistant subset of CSCs is that they repopulate a tumor resistant to the original intervention. The cellular programs driving the uncontrolled proliferation of many solid tumors result from aberrant activity of Wnt, Shh, and/or Notch signaling pathways in esc. Thus, therapies that down-regulate the activity of these fundamental pathways in CSCs will be effective in the treatment of cancer. The investigator's research program focuses on the elucidation of signaling mechanisms, control of cellular processes and discovery of small molecules that selectively target Wnt, Shh, and Notch signaling pathways that are fundamental to CSCs. Our preliminary results identified a novel Notch associated protein NACK that functions as a transcriptional co-activator of Notch. Moreover, Nack is expressed in human solid tumors and is required for cell survival and tumor growth in notch -dependent tumor cells. The investigator's aim is to further interrogate the link between Notch and Nack. Specific Aims: * Identify and isolate the cancer stem cell populations from primary chemo naive esophageal tumor samples. * Interrogate the status of the Notch,( the link between Notch and Nack), Wnt and Hedghog pathways in the chemo naive esophageal tumor as well as in specific cell populations, such as the CSC. * Determine the degree of cross-talk between t
Interventions
- PROCEDURE Tumor Biopsy via Ultrasound Endoscopy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2013-04-05 |
| Est. Completion | 2018-11-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02221245
The ClinicalTrials.gov registry entry for NCT02221245 describes a study currently listed as terminated, categorized as an unspecified phase. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Miami, which has 721 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Tumor Biopsy via Ultrasound Endoscopy is the first listed.
NCT02221245 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02221245 about?
NCT02221245 is a clinical study titled "Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients". Cancer results when undifferentiated cells grow in an uncontrolled manner, crowding out normal cells, causing morbidity and ultimately mortality. the cancer stem cell theory suggests that most tumors undergo a process of differentiation through which a relatively rare cancer stem or progenitor cell ...
What is the current status of trial NCT02221245?
This trial is currently terminated. The enrollment target is 24 participants. The study started on 2013-04-05. Estimated completion is 2018-11-07.
What interventions are being tested in trial NCT02221245?
The interventions under investigation include: Tumor Biopsy via Ultrasound Endoscopy (PROCEDURE).
Who is sponsoring clinical trial NCT02221245?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
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