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NCT02152670 · ClinicalTrials.gov registry record · NA
Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
A NA study, sponsored by Yale University.
- Terminated
- Registry status
- NA
- Development phase
- 1
- Enrollment target
NCT02152670 is a NA study that was terminated before completion, run by Yale University. The registered enrollment target is 1 participants.
The verdict
NCT02152670, a NA study, was terminated before completion, sponsored by Yale University.
- TERMINATED
- Registry status
- NA
- Development phase
- 1 participants
- Enrollment target
Study Summary
Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009). Among the first, most consistent, and broadly replicated of such findings in drug- (including cocaine) dependent individuals has been the reduction in subcortical (striatal) D2/3 receptors as imaged, most commonly, by the reversible, non-selective, D2/3 receptor antagonist radiotracer, \[11C\]raclopride. Certain dissociations on D2/3 availability by radioligand (\[11C\]raclopride vs. \[11C\]PHNO) and by brain region (striatum vs. SN; terminal vs. somatodendritic, respectively) are poorly understood in relationship to prior antagonist tracer results. In the current study the investigators will use pharmacological interventions (AMPT and methylphenidate) with both antagonist and agonist radiotracers to experimentally reconcile these discordant findings and clarify potential mechanistic inter-relationships.
Interventions
- DRUG Methylphenidate
- DRUG Alpha Methyl Para Tyrosine (AMPT)
- OTHER [11C]PHNO
- OTHER [11C]raclopride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2014-05 |
| Est. Completion | 2014-06-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02152670
The ClinicalTrials.gov registry entry for NCT02152670 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 1 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Methylphenidate is the first listed.
NCT02152670 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02152670 about?
NCT02152670 is a clinical study titled "Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET". Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009). Among the first, most consistent, and broadly replicated of such findings i...
What is the current status of trial NCT02152670?
This trial is currently terminated. It is a NA study. The enrollment target is 1 participants. The study started on 2014-05. Estimated completion is 2014-06-09.
What interventions are being tested in trial NCT02152670?
The interventions under investigation include: Methylphenidate (DRUG), Alpha Methyl Para Tyrosine (AMPT) (DRUG), [11C]PHNO (OTHER), [11C]raclopride (OTHER).
Who is sponsoring clinical trial NCT02152670?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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