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COMPLETED Phase 1

Phase I: Melphalan, Bendamustine and Carfilzomib for Autologous Transplant in Multiple Myeloma

NCT02148913 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase I clinical trial. Patients with a diagnosis of multiple myeloma undergoing autologous transplantation will receive a preparative regimen of melphalan, bendamustine, and carfilzomib. We hypothesize that the addition of carfilzomib to a conditioning regimen of melphalan and bendamustine in the setting of autologous transplantation for multiple myeloma is feasible and safe.

Conditions Studied

Interventions

  • DRUG Cohort 1: Carfilzomib 15 mg/m2
  • DRUG Cohort 2: Carfilzomib 20 mg/m2
  • DRUG Cohort 2b: Carfilzomib 20 mg/m2
  • DRUG Cohort 3b: Carfilzomib 27 mg/m2

Study Locations (1)

Michigan

  • Spectrum Health — Grand Rapids

Trial Details

FieldValue
Enrollment Target 18 participants
Start Date 2014-06
Est. Completion 2018-12
Phase Phase 1

Sponsor

Corewell Health West

15 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02148913

The ClinicalTrials.gov registry entry for NCT02148913 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Corewell Health West, which has 15 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Cohort 1: Carfilzomib 15 mg/m2 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02148913 reports 1 study location spanning 1 distinct geographic area — top geographies include Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02148913 about?

NCT02148913 is a clinical study titled "Phase I: Melphalan, Bendamustine and Carfilzomib for Autologous Transplant in Multiple Myeloma". This is a phase I clinical trial. Patients with a diagnosis of multiple myeloma undergoing autologous transplantation will receive a preparative regimen of melphalan, bendamustine, and carfilzomib. We hypothesize that the addition of carfilzomib to a conditioning regimen of melphalan and bendamustin...

What is the current status of trial NCT02148913?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2014-06. Estimated completion is 2018-12.

What conditions does trial NCT02148913 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02148913?

The interventions under investigation include: Cohort 1: Carfilzomib 15 mg/m2 (DRUG), Cohort 2: Carfilzomib 20 mg/m2 (DRUG), Cohort 2b: Carfilzomib 20 mg/m2 (DRUG), Cohort 3b: Carfilzomib 27 mg/m2 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02148913?

This trial is sponsored by Corewell Health West, which has 15 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02148913 being conducted?

This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial