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NCT02128711 · ClinicalTrials.gov registry record
Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens
A clinical trial, sponsored by University of Minnesota.
- Completed
- Registry status
- 74
- Enrollment target
NCT02128711: Completed study, sponsored by University of Minnesota.
NCT02128711 is a clinical trial that has completed, run by University of Minnesota. The registered enrollment target is 74 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02128711 has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- 74 participants
- Enrollment target
Study Summary
There is plenty of evidence to suggest that the lung is not uniform. The internal surface area is 30 times that of skin, and the different bronchioles/bronchi/alveoli differ greatly in blood perfusion, temperature, oxygen tension, and pH. Also, particularly in the context of respiratory disease, notable differences are present in the structure of epithelial cells, cilia, production of mucus, and inflammatory/immune responses. All of these factors are known to impact the physiology of bacteria, yet, there is very little understanding of how they impact a) the presence/absence of particular bacterial species throughout the respiratory tract, or b) the metabolic processes used by these bacteria within the human host environment. A greater understanding of the relationships between environmental (chemical) gradients in the lungs of diseased patients (particularly those with cystic fibrosis) and the microbial communities that are present may lead to novel hypotheses about manipulation of the respiratory environment for therapeutic benefit. To investigate this further, the investigators propose to use explanted lung specimens from cystic fibrosis patients to test the following hypothesis: Hypothesis: In patients with cystic fibrosis, bacterial community composition, metabolism and environmental chemistry will vary depending on their spatial location within the airways.
Primary Outcome
16S culture-independent sequencing will be used to characterize the spatial distribution of bacterial pathogens throughout the lungs of cystic fibrosis patients. Explanted lung specimens will be dissected into 5 separate lobes, and mucus material will be collected, homogenized, and processed for bacterial species identification.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2014-07-01 |
| Est. Completion | 2025-07-31 |
What the finished NCT02128711 record still lists
NCT02128711 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 74 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02128711 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02128711 about?
NCT02128711 is a clinical study titled "Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens". There is plenty of evidence to suggest that the lung is not uniform. The internal surface area is 30 times that of skin, and the different bronchioles/bronchi/alveoli differ greatly in blood perfusion, temperature, oxygen tension, and pH. Also, particularly in the context of respiratory disease, not...
What is the current status of trial NCT02128711?
This trial is currently completed. The enrollment target is 74 participants. The study started on 2014-07-01. Estimated completion is 2025-07-31.
Who is sponsoring clinical trial NCT02128711?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
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