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NCT02094755 · ClinicalTrials.gov registry record
Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)
A clinical trial, sponsored by University of Southern California.
- Completed
- Registry status
- 100
- Enrollment target
NCT02094755: Completed study, sponsored by University of Southern California.
NCT02094755 is a clinical trial that has completed, run by University of Southern California. The registered enrollment target is 100 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02094755 has completed, sponsored by University of Southern California.
- COMPLETED
- Registry status
- 100 participants
- Enrollment target
Study Summary
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity. CLI is a major cause of death and disability (secondary to myocardial infarction, stroke and amputation). The mortality in patients with CLI approaches 25% and 50% at one and five years respectively. High on-treatment platelet reactivity (HPR) in patients treated with aspirin and clopidogrel (previously referred to as "resistance") is associated with an increased risk of recurrent cardiovascular events after percutaneous coronary interventions and acute coronary syndromes. The prevalence and significance of High on-treatment Platelet Reactivity (HPR) in patients with critical limb ischemia treated with aspirin and/or clopidogrel is not known. The investigators project aims to investigate the prevalence of HPR (to aspirin and clopidogrel) in one hundred patients with diagnosis of critical limb ischemia encountered at University of Southern California (USC) affiliated hospitals (Los Angeles County Hospital and Keck Hospital of University of Southern California).
Primary Outcome
Platelet inhibition to aspirin will be evaluated with the VerifyNow® aspirin (ASA) test. Clopidogrel platelet inhibition will be evaluated with two different tests: the vasodilator-stimulated phosphoprotein (VASP) and the VerifyNow® purinergic receptor P2Y12 (VN-P2Y12) assays.
Interventions
- OTHER Blood draw only
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2013-06-19 |
| Est. Completion | 2017-01-31 |
What the finished NCT02094755 record still lists
NCT02094755 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Blood draw only is the first listed.
NCT02094755 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02094755 about?
NCT02094755 is a clinical study titled "Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)". Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity. CLI is a major cause of death and disability (secondary to myocardial infarction, stroke and amputation). The mortality in pat...
What is the current status of trial NCT02094755?
This trial is currently completed. The enrollment target is 100 participants. The study started on 2013-06-19. Estimated completion is 2017-01-31.
What interventions are being tested in trial NCT02094755?
The interventions under investigation include: Blood draw only (OTHER).
Who is sponsoring clinical trial NCT02094755?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
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