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NCT02086526 · ClinicalTrials.gov registry record · Phase 1
Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET)
A Phase 1 study, sponsored by Mayo Clinic.
- Completed
- Registry status
- Phase 1
- Development phase
- 68
- Enrollment target
NCT02086526: Completed Phase 1 study, sponsored by Mayo Clinic.
NCT02086526 is a Phase 1 study that has completed, run by Mayo Clinic. The registered enrollment target is 68 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02086526, a Phase 1 study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 68 participants
- Enrollment target
Study Summary
The investigator's global hypothesis is that women with Polycystic Ovary Syndrome (PCOS) can be separated into subtypes based on their response to metformin. The investigators propose here to use both targeted and non-targeted metabolomic approach to identify pathways associated with metformin's effect on insulin sensitivity and endothelial function. This pilot project will be the foundation for developing tailored therapeutic approaches to Polycystic Ovary Syndrome and identifying novel drug targets.
Primary Outcome
Insulin sensitivity will be calculated using an oral glucose minimal model. Insulin under the curve will be calculated geometrically with the trapezoidal rule.
Interventions
- DRUG Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2014-03 |
| Est. Completion | 2016-11-20 |
| Phase | Phase 1 |
What the finished NCT02086526 record still lists
NCT02086526 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 1 intervention - of which Metformin is the first listed.
NCT02086526 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02086526 about?
NCT02086526 is a clinical study titled "Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET)". The investigator's global hypothesis is that women with Polycystic Ovary Syndrome (PCOS) can be separated into subtypes based on their response to metformin. The investigators propose here to use both targeted and non-targeted metabolomic approach to identify pathways associated with metformin's eff...
What is the current status of trial NCT02086526?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 68 participants. The study started on 2014-03. Estimated completion is 2016-11-20.
What interventions are being tested in trial NCT02086526?
The interventions under investigation include: Metformin (DRUG).
Who is sponsoring clinical trial NCT02086526?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02086526's enrollment target sits among peer trials
68 776th of 2000 higher than 1,219 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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