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NCT01993836 · ClinicalTrials.gov registry record · Phase 4
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
A Phase 4 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 4
- Development phase
- 191
- Enrollment target
NCT01993836: Completed Phase 4 study, sponsored by Duke University.
NCT01993836 is a Phase 4 study that has completed, run by Duke University. The registered enrollment target is 191 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01993836, a Phase 4 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 191 participants
- Enrollment target
Study Summary
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connectivity. The investigators will also examine whether different types of anesthesia have different effects on these CSF markers of Alzheimers disease, or different effects on thinking and memory after anesthesia and surgery, or differential effects on the correlation between cognitive changes and CSF marker changes.
Primary Outcome
Spearman correlation was used here as the CSF markers follow a skewed distribution. Spearman correlation describes the strength of the monotonic relationship between two measures and is bounded between -1 and 1. Negative values indicate an inverse relationship while positive values mean that the variables move in tandem.
Interventions
- DRUG Total intravenous anesthesia with propofol
- DRUG General anesthesia with isoflurane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 191 participants |
| Start Date | 2013-11 |
| Est. Completion | 2019-01-10 |
| Phase | Phase 4 |
What the finished NCT01993836 record still lists
NCT01993836 is an interventional study that assigns participants to a tested intervention. The registered 191 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower).
The record links to 0 conditions, and to 2 interventions - of which Total intravenous anesthesia with propofol is the first listed.
NCT01993836 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01993836 about?
NCT01993836 is a clinical study titled "Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care". This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connecti...
What is the current status of trial NCT01993836?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 191 participants. The study started on 2013-11. Estimated completion is 2019-01-10.
What interventions are being tested in trial NCT01993836?
The interventions under investigation include: Total intravenous anesthesia with propofol (DRUG), General anesthesia with isoflurane (DRUG).
Who is sponsoring clinical trial NCT01993836?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01993836's enrollment target sits among peer trials
191 453rd of 2000 higher than 1,548 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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