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NCT01993147 · ClinicalTrials.gov registry record · NA
Functional Differences in Effortful Control
A NA study, sponsored by University of Michigan.
- Terminated
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT01993147: Clinical Trial NA study, sponsored by University of Michigan.
NCT01993147 is a NA study that was terminated before completion, run by University of Michigan. The registered enrollment target is 50 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01993147, a NA study, was terminated before completion, sponsored by University of Michigan.
- TERMINATED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
The purpose of this study was to learn more about the brain circuits involved with effortful control in healthy adult participants. It was planned that the study would enroll 80 participants to a dual task paradigm pilot while undergoing a fMRI scan to assess brain mechanisms that cause the "depletion effect". This effect refers to the observation that people perform more poorly on effortful control tasks after they have already performed task requiring effortful control. Then subsequent study participants would be given either methylphenidate (also known as 'Ritalin') which is FDA approved and the most widely-used medication for Attention Deficit Hyperactivity Disorder (ADHD) or a placebo, which is a sugar pill. Each participant would also perform some computer tasks that have been shown in previous studies to require effortful control while undergoing an fMRI (functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain. The study's goal was to learn more about the brain mechanisms by which methylphenidate improves effortful control. After enrolling the first 50 participants, the study assessed whether a depletion effect was observed in the dual task paradigm. It was found that there was not: there was no statistically significant difference in effortful control performance comparing subjects who did and did not perform a prior effortful control task. Because the behavioral manipulation failed, it was determined that the drug manipulation portion of the study was no longer justified. Thus, after enrolling 50 participants to the pilot part of the study, the decision was made to terminate the study without beginning the trial of methylphenidate.
Interventions
- BEHAVIORAL Dual task paradigm pilot
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2014-09-12 |
| Est. Completion | 2015-06-08 |
| Phase | NA |
Why NCT01993147 stopped before completion
NCT01993147 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Dual task paradigm pilot is the first listed.
NCT01993147 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01993147 about?
NCT01993147 is a clinical study titled "Functional Differences in Effortful Control". The purpose of this study was to learn more about the brain circuits involved with effortful control in healthy adult participants. It was planned that the study would enroll 80 participants to a dual task paradigm pilot while undergoing a fMRI scan to assess brain mechanisms that cause the "depleti...
What is the current status of trial NCT01993147?
This trial is currently terminated. It is a NA study. The enrollment target is 50 participants. The study started on 2014-09-12. Estimated completion is 2015-06-08.
What interventions are being tested in trial NCT01993147?
The interventions under investigation include: Dual task paradigm pilot (BEHAVIORAL).
Who is sponsoring clinical trial NCT01993147?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01993147's enrollment target sits among peer trials
50 1279th of 2000 higher than 622 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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