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NCT01993147 · ClinicalTrials.gov registry record · NA
Functional Differences in Effortful Control
A NA study, sponsored by University of Michigan.
- Terminated
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT01993147 is a NA study that was terminated before completion, run by University of Michigan. The registered enrollment target is 50 participants.
The verdict
NCT01993147, a NA study, was terminated before completion, sponsored by University of Michigan.
- TERMINATED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
The purpose of this study was to learn more about the brain circuits involved with effortful control in healthy adult participants. It was planned that the study would enroll 80 participants to a dual task paradigm pilot while undergoing a fMRI scan to assess brain mechanisms that cause the "depletion effect". This effect refers to the observation that people perform more poorly on effortful control tasks after they have already performed task requiring effortful control. Then subsequent study participants would be given either methylphenidate (also known as 'Ritalin') which is FDA approved and the most widely-used medication for Attention Deficit Hyperactivity Disorder (ADHD) or a placebo, which is a sugar pill. Each participant would also perform some computer tasks that have been shown in previous studies to require effortful control while undergoing an fMRI (functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain. The study's goal was to learn more about the brain mechanisms by which methylphenidate improves effortful control. After enrolling the first 50 participants, the study assessed whether a depletion effect was observed in the dual task paradigm. It was found that there was not: there was no statistically significant difference in effortful control performance comparing subjects who did and did not perform a prior effortful control task. Because the behavioral manipulation failed, it was determined that the drug manipulation portion of the study was no longer justified. Thus, after enrolling 50 participants to the pilot part of the study, the decision was made to terminate the study without beginning the trial of methylphenidate.
Interventions
- BEHAVIORAL Dual task paradigm pilot
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2014-09-12 |
| Est. Completion | 2015-06-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01993147
The ClinicalTrials.gov registry entry for NCT01993147 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,327 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Dual task paradigm pilot is the first listed.
NCT01993147 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01993147 about?
NCT01993147 is a clinical study titled "Functional Differences in Effortful Control". The purpose of this study was to learn more about the brain circuits involved with effortful control in healthy adult participants. It was planned that the study would enroll 80 participants to a dual task paradigm pilot while undergoing a fMRI scan to assess brain mechanisms that cause the "depleti...
What is the current status of trial NCT01993147?
This trial is currently terminated. It is a NA study. The enrollment target is 50 participants. The study started on 2014-09-12. Estimated completion is 2015-06-08.
What interventions are being tested in trial NCT01993147?
The interventions under investigation include: Dual task paradigm pilot (BEHAVIORAL).
Who is sponsoring clinical trial NCT01993147?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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