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NCT01984476 · ClinicalTrials.gov registry record
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
A clinical trial, sponsored by James J. Peters Veterans Affairs Medical Center.
- Completed
- Registry status
- 120
- Enrollment target
NCT01984476: Completed study, sponsored by James J. Peters Veterans Affairs Medical Center.
NCT01984476 is a clinical trial that has completed, run by James J. Peters Veterans Affairs Medical Center. The registered enrollment target is 120 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01984476 has completed, sponsored by James J. Peters Veterans Affairs Medical Center.
- COMPLETED
- Registry status
- 120 participants
- Enrollment target
Study Summary
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced life expectancies. Decentralized autonomic regulation in persons with SCI results in a multitude of cardiovascular changes, which may contribute to accelerated aging. Adverse cardiovascular changes may have deleterious effects on cerebral blood flow dynamics and an increase in cerebral vascular resistance index in individuals with SCI during cognitive testing. Deficits in memory and processing speed in individuals with SCI may relate to cardiovascular and cerebrovascular dysfunction. Identifying the associations between healthy aging versus premature or accelerated aging in organ system function in the SCI population is an important first step towards prevention and amelioration of these changes. Therefore the study objectives are to compare, among individuals with SCI, age-matched non-SCI and older non-SCI individuals arterial stiffness and cerebral vascular resistance index; memory, processing speed, and executive function; and volume of white matter hyperintensities. 60 individuals with SCI, 30 age-matched non-SCI controls, and 20 older non-SCI controls will be recruited for this study. All potential subjects will undergo a two-part screening process which consists of an initial screening via telephone and a detailed, in-person screening. Eligible subjects will be invited to participate in a 4 hour laboratory visit during which their arterial stiffness, blood pressure, heart rate, respiration rate and, blood flow to the brain will be monitored at rest and during a comprehensive series of cognitive tests. A subset of the participants will be asked to take part in an MRI brain imaging session: 40 persons with SCI, 10 age-matched non-SCI and 10 older non-SCI. Eligible subjects will be asked to participate in a 1 hour MRI/functional magnetic res
Primary Outcome
To determine the difference in arterial stiffness among individuals with SCI to age-matched non-SCI and older non-SCI.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2013-07 |
| Est. Completion | 2017-07 |
What the finished NCT01984476 record still lists
NCT01984476 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01984476 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01984476 about?
NCT01984476 is a clinical study titled "Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury". As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced life expectancies. Decentralized autonomic regulation in persons with SCI ...
What is the current status of trial NCT01984476?
This trial is currently completed. The enrollment target is 120 participants. The study started on 2013-07. Estimated completion is 2017-07.
Who is sponsoring clinical trial NCT01984476?
This trial is sponsored by James J. Peters Veterans Affairs Medical Center, which has 39 total clinical trials registered on ClinicalTrials.gov.
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