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NCT01982695 · ClinicalTrials.gov registry record · NA
Cardiomyopathy in DMD: Lisinopril vs. Losartan
A NA study, sponsored by Nationwide Children's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 23
- Enrollment target
NCT01982695 is a NA study that has completed, run by Nationwide Children's Hospital. The registered enrollment target is 23 participants.
The verdict
NCT01982695, a NA study, has completed, sponsored by Nationwide Children's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 23 participants
- Enrollment target
Study Summary
This trial is a double-blind randomized clinical trial of lisinopril versus losartan for the treatment of cardiomyopathy in Duchenne Muscular Dystrophy (DMD). Both drugs are known to be effective for the treatment of dilated cardiomyopathy. ACEi have been reported to delay the onset and progression of left ventricle dysfunction in children with DMD. Multiple studies show therapeutic efficacy of losartan in animals with cardiomyopathy related to muscular dystrophy and in patients with cardiomyopathy from diverse causes. ARBs are often reserved for patients in whom heart failure is not adequately treated or where side effects preclude the use of an ACEi. However, in DMD, losartan might be a better choice as a first line drug because of studies demonstrating a potential benefit for skeletal muscle in the mdx mouse. Considering that both skeletal and cardiac muscles are major contributors of the disability of DMD, a drug that could improve both heart and skeletal muscles simultaneously would need consideration as the drug of choice for the cardiomyopathic DMD patient.
Interventions
- DRUG Losartan
- DRUG Lisinopril
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2009-03 |
| Est. Completion | 2013-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01982695
The ClinicalTrials.gov registry entry for NCT01982695 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 23 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nationwide Children's Hospital, which has 188 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Losartan is the first listed.
NCT01982695 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01982695 about?
NCT01982695 is a clinical study titled "Cardiomyopathy in DMD: Lisinopril vs. Losartan". This trial is a double-blind randomized clinical trial of lisinopril versus losartan for the treatment of cardiomyopathy in Duchenne Muscular Dystrophy (DMD). Both drugs are known to be effective for the treatment of dilated cardiomyopathy. ACEi have been reported to delay the onset and progression ...
What is the current status of trial NCT01982695?
This trial is currently completed. It is a NA study. The enrollment target is 23 participants. The study started on 2009-03. Estimated completion is 2013-09.
What interventions are being tested in trial NCT01982695?
The interventions under investigation include: Losartan (DRUG), Lisinopril (DRUG).
Who is sponsoring clinical trial NCT01982695?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
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