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NCT01974180 · ClinicalTrials.gov registry record
Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Terminated
- Registry status
- 48
- Enrollment target
NCT01974180: Clinical Trial study, sponsored by Weill Medical College of Cornell University.
NCT01974180 is a clinical trial that was terminated before completion, run by Weill Medical College of Cornell University. The registered enrollment target is 48 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01974180 was terminated before completion, sponsored by Weill Medical College of Cornell University.
- TERMINATED
- Registry status
- 48 participants
- Enrollment target
Study Summary
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of differentiated airway epithelium. Based on our preliminary observations that epidermal growth factor receptor, known to regulate airway epithelial differentiation, is enriched in BC and its ligand EGF is induced by smoking, we hypothesized that smoking-induced EGF alters the ability of BC to form normally differentiated airway epithelium. To test this, airway BC will be purified using a cell-culture method established in our laboratory and responses to EGF will be analyzed using genome-wide microarrays and an in vitro air-liquid interface model of airway epithelial differentiation.
Primary Outcome
To determine whether stimulation of airway BC from healthy nonsmokers with EGF induces genes and pathways related to smoking-associated phenotypes, e.g. BC hyperplasia, squamous metaplasia, mucous metaplasia, abnormal cilia, decreased Clara cell number and compromised junctional integrity.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2013-12-03 |
| Est. Completion | 2015-04-23 |
Why NCT01974180 stopped before completion
NCT01974180 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 48 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01974180 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01974180 about?
NCT01974180 is a clinical study titled "Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function". Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of diffe...
What is the current status of trial NCT01974180?
This trial is currently terminated. The enrollment target is 48 participants. The study started on 2013-12-03. Estimated completion is 2015-04-23.
Who is sponsoring clinical trial NCT01974180?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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