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NCT01974180 · ClinicalTrials.gov registry record
Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Terminated
- Registry status
- 48
- Enrollment target
NCT01974180 is a clinical trial that was terminated before completion, run by Weill Medical College of Cornell University. The registered enrollment target is 48 participants.
The verdict
NCT01974180 was terminated before completion, sponsored by Weill Medical College of Cornell University.
- TERMINATED
- Registry status
- 48 participants
- Enrollment target
Study Summary
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of differentiated airway epithelium. Based on our preliminary observations that epidermal growth factor receptor, known to regulate airway epithelial differentiation, is enriched in BC and its ligand EGF is induced by smoking, we hypothesized that smoking-induced EGF alters the ability of BC to form normally differentiated airway epithelium. To test this, airway BC will be purified using a cell-culture method established in our laboratory and responses to EGF will be analyzed using genome-wide microarrays and an in vitro air-liquid interface model of airway epithelial differentiation.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2013-12-03 |
| Est. Completion | 2015-04-23 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01974180
The ClinicalTrials.gov registry entry for NCT01974180 describes a study currently listed as terminated, categorized as an unspecified phase. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Weill Medical College of Cornell University, which has 701 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01974180 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01974180 about?
NCT01974180 is a clinical study titled "Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function". Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation. Airway basal cells (BC) are stem/progenitor cells necessary for generation of diffe...
What is the current status of trial NCT01974180?
This trial is currently terminated. The enrollment target is 48 participants. The study started on 2013-12-03. Estimated completion is 2015-04-23.
Who is sponsoring clinical trial NCT01974180?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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