Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01974154 · ClinicalTrials.gov registry record
COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Terminated
- Registry status
- 206
- Enrollment target
NCT01974154: Clinical Trial study, sponsored by Weill Medical College of Cornell University.
NCT01974154 is a clinical trial that was terminated before completion, run by Weill Medical College of Cornell University. The registered enrollment target is 206 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01974154 was terminated before completion, sponsored by Weill Medical College of Cornell University.
- TERMINATED
- Registry status
- 206 participants
- Enrollment target
Study Summary
Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated cells that mediate transport of mucus to remove inhaled pathogens. The focus of this study is to carry out metabolic profiling of banked biologic samples and assess the hypothesis that COPD is associated with a unique metabolome in serum and lung epithelial lining fluid, and that subsets of the COPD metabolome are linked to the ciliopathy of COPD.
Primary Outcome
We will perform metabolic profiling of biologic samples to assess the hypothesis that smoking-induced COPD is associated with a unique metabolome in serum and lung ELF, and that subsets of the COPD metabolome are linked to the ciliopathy of COPD.
Interventions
- OTHER Cohort I
- OTHER Cohort II
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2013-12 |
| Est. Completion | 2019-05 |
Why NCT01974154 stopped before completion
NCT01974154 is an observational study that tracks outcomes without assigning an intervention. The registered 206 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which Cohort I is the first listed.
NCT01974154 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01974154 about?
NCT01974154 is a clinical study titled "COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function". Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated cells that mediate transport of mucus to remove inhaled pathogens. The focus of this study is t...
What is the current status of trial NCT01974154?
This trial is currently terminated. The enrollment target is 206 participants. The study started on 2013-12. Estimated completion is 2019-05.
What interventions are being tested in trial NCT01974154?
The interventions under investigation include: Cohort I (OTHER), Cohort II (OTHER).
Who is sponsoring clinical trial NCT01974154?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03373968 · 206 participants · Phase 2
Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study
- NCT03550391 · 206 participants · Phase 3
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
- NCT04757116 · 206 participants · NA
Post-Market Study to Assess iTind Safety in Comparison to UroLift
- NCT05675865 · 206 participants · NA
Cryoablation for Monomorphic Ventricular Tachycardia
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia