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NCT01970696 · ClinicalTrials.gov registry record
International Ovarian & Testicular Stromal Tumor Registry
A clinical trial of Ovarian Sex-cord Stromal Tumor and Testicular Stromal Tumors, sponsored by Children's Hospitals and Clinics of Minnesota.
- Recruiting
- Registry status
- 300
- Enrollment target
- 1
- Study location
NCT01970696: Recruiting study of Ovarian Sex-cord Stromal Tumor and Testicular Stromal Tumors, sponsored by Children's Hospitals and Clinics of Minnesota.
NCT01970696 is a study of Ovarian Sex-cord Stromal Tumor and Testicular Stromal Tumors that is actively recruiting participants, run by Children's Hospitals and Clinics of Minnesota. The registered enrollment target is 300 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01970696, a study of Ovarian Sex-cord Stromal Tumor and Testicular Stromal Tumors, is actively recruiting participants, sponsored by Children's Hospitals and Clinics of Minnesota.
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to be associated with a lung cancer of early childhood called pleuropulmonary blastoma (PPB). The cause of these ovarian tumors is unknown. DICER1 mutations are seen in the majority of children with PPB. Research shows DICER1 mutations are also seen in some patients with ovarian tumors. Like PPB, ovarian stromal tumors are highly curable when found in early stage; however, later forms of the disease are aggressive and often fatal. The International Ovarian Stromal Tumor Registry collects clinical and biologic data to understand why these tumors occur and how to treat them. Current work involves the study of the role of DICER1 and miRNA expression in ovarian stromal tumors. Understanding the clinical history, predisposing factors and DICER1 and miRNA expression in these ovarian tumors of childhood will lead to targeted screening and risk stratification for evidence-based treatment and biologically rational therapies. These efforts will improve the lives of children by increasing survival and reducing late effects. The specific goals of the International Ovarian and Testicular Stromal Tumor Registry are: 1. to understand risk factors by studying age, pathologic subtype, histopathologic features, tumor invasiveness, degree of differentiation, presence of metastasis 2. to collect information on personal and family history in order to refine the clinical characteristics of patients and families with and without germline DICER1 mutations and other genetic predisposing factors 3. to determine whether there is a pattern of gene expression or DNA alterations that correlate with predisposition to ovarian tumors, biologic behavior and clinical outcome 4. to determine optimal screening regimens 5. to use clinical data obtained through the Registry to refine treatment algorit
Conditions Studied
Study Locations (1)
Minnesota
- Children's Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2011-12-08 |
| Est. Completion | 2030-12 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01970696
The ClinicalTrials.gov registry entry for NCT01970696 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Hospitals and Clinics of Minnesota, which has 31 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Ovarian Sex-cord Stromal Tumor appearing as the primary indexed condition, and to 0 interventions.
NCT01970696 reports 1 study location spanning 1 distinct geographic area - top geographies include Minnesota.
Frequently Asked Questions
What is clinical trial NCT01970696 about?
NCT01970696 is a clinical study titled "International Ovarian & Testicular Stromal Tumor Registry". Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to be associated with a lung cancer of early childhood called pleuropulmonary blastoma (PPB). T...
What is the current status of trial NCT01970696?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2011-12-08. Estimated completion is 2030-12.
What conditions does trial NCT01970696 study?
This clinical trial studies the following conditions: Ovarian Sex-cord Stromal Tumor, Testicular Stromal Tumors, Ovarian Small Cell Carcinoma.
Who is sponsoring clinical trial NCT01970696?
This trial is sponsored by Children's Hospitals and Clinics of Minnesota, which has 31 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01970696 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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