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NCT01962779 · ClinicalTrials.gov registry record · NA
Sleep, Aging and Risk for Alzheimer's Disease
A NA study, sponsored by NYU Langone Health.
- Completed
- Registry status
- NA
- Development phase
- 235
- Enrollment target
NCT01962779: Completed NA study, sponsored by NYU Langone Health.
NCT01962779 is a NA study that has completed, run by NYU Langone Health. The registered enrollment target is 235 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01962779, a NA study, has completed, sponsored by NYU Langone Health.
- COMPLETED
- Registry status
- NA
- Development phase
- 235 participants
- Enrollment target
Study Summary
Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial temporal lobe glucose uptake (FDG-PET) and volume (MRI) and progressive memory decline, all of which have been shown to be useful in predicting future dementia in older adults. These findings raise the question as to whether Alzheimer's disease (AD) tissue damage causes SDB in the elderly, or alternatively, if SDB acts as a risk factor for AD neurodegeneration. In the proposed study, we will investigate these mechanistic hypotheses in cognitively normal elderly by examining the longitudinal associations between SDB and cognitive decline, novel MR neuroimaging and CSF biomarkers for neurodegeneration; while our secondary goal is to launch a pilot treatment study to aid in interpreting the mechanistic hypotheses and to examine the effects of nasal continuous positive airway pressure (CPAP) on cognitive decline and neurodegeneration.
Primary Outcome
At cross section, levels of CSF P-Tau, T-Tau and Aβ42 (in pg/mL) in subjects with SDB
Interventions
- OTHER Continuous positive airway pressure (CPAP)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 235 participants |
| Start Date | 2013-07-31 |
| Est. Completion | 2017-05-03 |
| Phase | NA |
What the finished NCT01962779 record still lists
NCT01962779 is an interventional study that assigns participants to a tested intervention. The registered 235 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 1 intervention - of which Continuous positive airway pressure (CPAP) is the first listed.
NCT01962779 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01962779 about?
NCT01962779 is a clinical study titled "Sleep, Aging and Risk for Alzheimer's Disease". Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial temporal lobe glucose uptake (FDG-PET) and volume (MRI) and progressiv...
What is the current status of trial NCT01962779?
This trial is currently completed. It is a NA study. The enrollment target is 235 participants. The study started on 2013-07-31. Estimated completion is 2017-05-03.
What interventions are being tested in trial NCT01962779?
The interventions under investigation include: Continuous positive airway pressure (CPAP) (OTHER).
Who is sponsoring clinical trial NCT01962779?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01962779's enrollment target sits among peer trials
235 461st of 2000 higher than 1,539 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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