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NCT01899521 · ClinicalTrials.gov registry record · NA
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
A NA study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 113
- Enrollment target
NCT01899521: Completed NA study, sponsored by VA Office of Research and Development.
NCT01899521 is a NA study that has completed, run by VA Office of Research and Development. The registered enrollment target is 113 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01899521, a NA study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 113 participants
- Enrollment target
Study Summary
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans. The primary goal is to determine if either dietary zinc or S-adenosylmethionine (SAMe) can augment lung immune defenses in alcoholics and thereby decrease the risk of lung injury and infection.
Primary Outcome
Improvement in alveolar macrophage phagocytic index. Phagocytic index will be measured before and after treatment phase. Phagocytic index is calculated using isolated alveolar macrophages from the bronchoscopy procedure such that phagocytic index = (total number of engulfed cells/total number of counted macrophages) x (number of macrophages containing engulfed cells/total number of counted macrophages) x 100.
Interventions
- PROCEDURE Bronchoscopy
- DIETARY_SUPPLEMENT Zinc sulfate 220 mg once daily
- DIETARY_SUPPLEMENT S-adenosylmethionine 400 mg twice daily
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2013-05-01 |
| Est. Completion | 2017-07-31 |
| Phase | NA |
What the finished NCT01899521 record still lists
NCT01899521 is an interventional study that assigns participants to a tested intervention. The registered 113 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 3 interventions - of which Bronchoscopy is the first listed.
NCT01899521 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01899521 about?
NCT01899521 is a clinical study titled "Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics". This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans. The primary goal is to determine if either dietary zinc or S-adenosylmethionine (SAMe) can augment lung immune defenses in alcoholics and thereby decrease the ri...
What is the current status of trial NCT01899521?
This trial is currently completed. It is a NA study. The enrollment target is 113 participants. The study started on 2013-05-01. Estimated completion is 2017-07-31.
What interventions are being tested in trial NCT01899521?
The interventions under investigation include: Bronchoscopy (PROCEDURE), Zinc sulfate 220 mg once daily (DIETARY_SUPPLEMENT), S-adenosylmethionine 400 mg twice daily (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01899521?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01899521's enrollment target sits among peer trials
113 813th of 2000 higher than 1,188 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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