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NCT01881828 · ClinicalTrials.gov registry record · Phase 3
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
A Phase 3 study, sponsored by Jaeb Center for Health Research.
- Completed
- Registry status
- Phase 3
- Development phase
- 164
- Enrollment target
NCT01881828: Completed Phase 3 study, sponsored by Jaeb Center for Health Research.
NCT01881828 is a Phase 3 study that has completed, run by Jaeb Center for Health Research. The registered enrollment target is 164 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (79% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01881828, a Phase 3 study, has completed, sponsored by Jaeb Center for Health Research.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 164 participants
- Enrollment target
Study Summary
The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-\<20 years, with type 1 diabetes for at least 1 year. Secondary objectives are to assess the effect of metformin on C-peptide levels, a measure of how much insulin is still being produced by the beta cells of the pancreas, and on vascular dysfunction. In addition, an ancillary study is planned to assess if metformin will improve tissue-specific insulin resistance in type 1 diabetes using a hyperinsulinemic euglycemic clamp.
Primary Outcome
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months
Interventions
- DRUG Metformin (glucophage)
- OTHER oral placebo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 164 participants |
| Start Date | 2013-09 |
| Est. Completion | 2014-12 |
| Phase | Phase 3 |
What the finished NCT01881828 record still lists
NCT01881828 is an interventional study that assigns participants to a tested intervention. The registered 164 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (79% lower).
The record links to 0 conditions, and to 2 interventions - of which Metformin (glucophage) is the first listed.
NCT01881828 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01881828 about?
NCT01881828 is a clinical study titled "Metformin Therapy for Overweight Adolescents With Type 1 Diabetes". The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-\<20 years, with type 1 diabetes for at least 1 year. Secondary objectives are to assess the effect o...
What is the current status of trial NCT01881828?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 164 participants. The study started on 2013-09. Estimated completion is 2014-12.
What interventions are being tested in trial NCT01881828?
The interventions under investigation include: Metformin (glucophage) (DRUG), oral placebo (OTHER).
Who is sponsoring clinical trial NCT01881828?
This trial is sponsored by Jaeb Center for Health Research, which has 119 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01881828's enrollment target sits among peer trials
164 1470th of 2000 higher than 530 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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