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NCT01855360 · ClinicalTrials.gov registry record · Phase 1
Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
A Phase 1 study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT01855360: Completed Phase 1 study, sponsored by Brigham and Women's Hospital.
NCT01855360 is a Phase 1 study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01855360, a Phase 1 study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
The objective of the study is to determine whether the combination of the bile acid TUDCA, and doxycycline will slow the progression of familial and senile amyloidosis.
Primary Outcome
Outcome measure, namely changes in longitudinal echocardiographic strain, will be compared to previously determined changes derived from a cohort of patients with TTR cardiac amyloidosis who were not receiving specific therapy for amyloid deposition.
Interventions
- DRUG Tauroursodeoxycholic Acid and Doxycycline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2013-06 |
| Est. Completion | 2015-05-31 |
| Phase | Phase 1 |
What the finished NCT01855360 record still lists
NCT01855360 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 1 intervention - of which Tauroursodeoxycholic Acid and Doxycycline is the first listed.
NCT01855360 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01855360 about?
NCT01855360 is a clinical study titled "Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy". The objective of the study is to determine whether the combination of the bile acid TUDCA, and doxycycline will slow the progression of familial and senile amyloidosis.
What is the current status of trial NCT01855360?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2013-06. Estimated completion is 2015-05-31.
What interventions are being tested in trial NCT01855360?
The interventions under investigation include: Tauroursodeoxycholic Acid and Doxycycline (DRUG).
Who is sponsoring clinical trial NCT01855360?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01855360's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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