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NCT01829165 · ClinicalTrials.gov registry record · NA
Brain Imaging of rTMS Treatment for Depression
A NA study, sponsored by Stanford University.
- Completed
- Registry status
- NA
- Development phase
- 85
- Enrollment target
NCT01829165: Completed NA study, sponsored by Stanford University.
NCT01829165 is a NA study that has completed, run by Stanford University. The registered enrollment target is 85 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01829165, a NA study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- NA
- Development phase
- 85 participants
- Enrollment target
Study Summary
The overarching goal of this research program is to elucidate causal and directional neural network- level abnormalities in depression, and how they are modulated by an individually-tailored, circuit-directed intervention. By using concurrent TMS and fMRI, the investigators can overcome a major limitation of neuroimaging - the inability to demonstrate causality. The investigators' findings will serve as a platform for future studies wherein TMS treatment can be directly guided by the investigators' ability to image and causally manipulate specific neural networks. Aim 1: To examine causal interactions between two major brain networks in depression. Aim 2: To examine the impact of antidepressant TMS on causal network abnormalities in depression. Hypothesis 1: Depressed subjects will show blunted responses, compared to healthy controls, in two targeted and interacting networks, using concurrent transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Hypothesis 2: Treatment of patients with high-frequency repetitive TMS (rTMS) will result in normalization of baseline network-level deficits, and be predicted by degree of baseline network abnormalities.
Primary Outcome
The Hamilton Depression Rating Scale (HAM-D) is a 24-item clinician-administered assessment utilized as a way of determining a patient's level of depression before, during, and after treatment. It takes approximately 15-20 minutes to complete the interview and score the results. Subscale scores are 0-2 (10 questions), 0-3 (2 questions), and 0-4 (12 questions). Subscales are totaled for an overall score (range 0 -76). For the overall score and all subscales, lower scores correspond to fewer sympt
Interventions
- DEVICE rTMS Treatment
- DEVICE Sham rTMS Treatment
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2012-09 |
| Est. Completion | 2017-01-20 |
| Phase | NA |
What the finished NCT01829165 record still lists
NCT01829165 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which rTMS Treatment is the first listed.
NCT01829165 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01829165 about?
NCT01829165 is a clinical study titled "Brain Imaging of rTMS Treatment for Depression". The overarching goal of this research program is to elucidate causal and directional neural network- level abnormalities in depression, and how they are modulated by an individually-tailored, circuit-directed intervention. By using concurrent TMS and fMRI, the investigators can overcome a major limi...
What is the current status of trial NCT01829165?
This trial is currently completed. It is a NA study. The enrollment target is 85 participants. The study started on 2012-09. Estimated completion is 2017-01-20.
What interventions are being tested in trial NCT01829165?
The interventions under investigation include: rTMS Treatment (DEVICE), Sham rTMS Treatment (DEVICE).
Who is sponsoring clinical trial NCT01829165?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01829165's enrollment target sits among peer trials
85 980th of 2000 higher than 1,018 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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