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NCT01821638 · ClinicalTrials.gov registry record
Brain Alterations and Cognitive Impairment in Older Adults With Heart Failure
A clinical trial, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- 40
- Enrollment target
NCT01821638: Completed study, sponsored by University of Wisconsin, Madison.
NCT01821638 is a clinical trial that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 40 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01821638 has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- 40 participants
- Enrollment target
Study Summary
Cognitive impairment, commonly reported as difficulty with memory and executive function, is a widely recognized clinical challenge for older persons with heart failure (HF). Little is known about the relationship between brain MRI and cognitive impairment in older persons with HF. A limited number of studies have investigated brain MRI in adults with HF and produced conflicting results. Previous findings are limited by use of lower resolution scanners (1.5 Tesla), lack of MRI techniques (i.e. combining structural sequences with perfusion sequences) and recruitment of mixed age samples. Based on these limitations, the purpose of this research plan is to explore the relationship between brain MRI and cognitive impairment in older persons with HF using high resolution structural and perfusion scans. To accomplish this goal, investigators will compare 40 adults with HF who are age \> 65 years old with 40 healthy, gender, age, and education matched controls. Investigators will obtain neuropsychological measures of multiple domains, as well as MRI measurements of the temporal lobe and prefrontal cortex at baseline and 12-months.
Primary Outcome
Compare mean values of the following outcomes between older adults with heart failure and older adults without heart failure at baseline * neuropsychological test scores * brain medial temporal lobe volume * brain frontal cortex volume * brain medial temporal lobe perfusion * brain frontal cortex perfusion Compare mean value changes in the following outcomes between baseline and one year in patients with heart failure: * neuropsychological test scores * brain medial temporal lobe volume * bra
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2013-04-01 |
| Est. Completion | 2018-12-31 |
What the finished NCT01821638 record still lists
NCT01821638 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01821638 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01821638 about?
NCT01821638 is a clinical study titled "Brain Alterations and Cognitive Impairment in Older Adults With Heart Failure". Cognitive impairment, commonly reported as difficulty with memory and executive function, is a widely recognized clinical challenge for older persons with heart failure (HF). Little is known about the relationship between brain MRI and cognitive impairment in older persons with HF. A limited number ...
What is the current status of trial NCT01821638?
This trial is currently completed. The enrollment target is 40 participants. The study started on 2013-04-01. Estimated completion is 2018-12-31.
Who is sponsoring clinical trial NCT01821638?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
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