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NCT01758224 · ClinicalTrials.gov registry record · NA
Expiratory Muscle Conditioning in Multiple Sclerosis Using Magnetic Stimulation
A NA study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT01758224: Completed NA study, sponsored by The Cleveland Clinic.
NCT01758224 is a NA study that has completed, run by The Cleveland Clinic. The registered enrollment target is 4 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01758224, a NA study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
Multiple sclerosis (MS) is a primary disorder of the central nervous system that may affect motor pathways and cause muscle weakness. Respiratory complications due to respiratory muscle weakness are common in the terminal stages of MS and contribute to mortality in these patients. Respiratory muscle weakness may also impair the performance of coughing and aspiration, pneumonia, or even acute ventilatory failure may ensue. Functional magnetic stimulation (FMS) is a non-invasive method that promotes the contraction of muscles through nerve activation. Over the last few years, the study investigators have demonstrated efficacy of FMS technology for stimulating respiratory muscles in animal models, able-bodied subjects \[3\] and spinal cord injured (SCI) patients \[4\]. In this study, the researchers will investigate the efficacy of using FMS technique for respiratory muscle conditioning in patients with MS. Furthermore, the investigators will also compare expiration related outcomes of FMS technique with resistive expiratory muscle training (REMT) methodology. Hypotheses 1. FMS conditioning of the expiratory muscles can generate significant expiratory flows and pressures in patients with MS. 2. FMS conditioning of expiratory muscles is more effective compared to resistive expiratory muscle training (REMT) in patients with MS.
Primary Outcome
Changes in participant's pulmonary (lung) function will be assessed using a non-invasive pulmonary function test (PFT).
Interventions
- OTHER Functional Magnetic Stimulation
- OTHER Resistive Expiratory Muscle Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2012-09 |
| Est. Completion | 2015-09 |
| Phase | NA |
What the finished NCT01758224 record still lists
NCT01758224 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which Functional Magnetic Stimulation is the first listed.
NCT01758224 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01758224 about?
NCT01758224 is a clinical study titled "Expiratory Muscle Conditioning in Multiple Sclerosis Using Magnetic Stimulation". Multiple sclerosis (MS) is a primary disorder of the central nervous system that may affect motor pathways and cause muscle weakness. Respiratory complications due to respiratory muscle weakness are common in the terminal stages of MS and contribute to mortality in these patients. Respiratory muscle...
What is the current status of trial NCT01758224?
This trial is currently completed. It is a NA study. The enrollment target is 4 participants. The study started on 2012-09. Estimated completion is 2015-09.
What interventions are being tested in trial NCT01758224?
The interventions under investigation include: Functional Magnetic Stimulation (OTHER), Resistive Expiratory Muscle Training (OTHER).
Who is sponsoring clinical trial NCT01758224?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01758224's enrollment target sits among peer trials
4 1996th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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