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NCT01737671 · ClinicalTrials.gov registry record · Early Phase 1
Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study
A Early Phase 1 study, sponsored by M.D. Anderson Cancer Center.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 7
- Enrollment target
NCT01737671: Completed Early Phase 1 study, sponsored by M.D. Anderson Cancer Center.
NCT01737671 is a Early Phase 1 study that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 7 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01737671, a Early Phase 1 study, has completed, sponsored by M.D. Anderson Cancer Center.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 7 participants
- Enrollment target
Study Summary
The goal of this clinical research study is to learn if it is safe to receive methotrexate through the fourth ventricle of the brain in patients with brain tumors. Methotrexate is designed to block cancer cells from dividing, which may slow or stop their growth and spread throughout the body. This may cause the cancer cells to die.
Primary Outcome
New neurological deficit defined as new cranial neuropathy, nystagmus, change in mental status, motor deficit, or cerebellar finding (ataxia, dysmetria, dysdiadochokinesis) that is attributed by treating physicians to intraventricular methotrexate infusions.
Interventions
- DRUG Leucovorin
- DRUG Methotrexate
- PROCEDURE Ommaya Reservoir
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2012-12-27 |
| Est. Completion | 2018-01-11 |
| Phase | Early Phase 1 |
What the finished NCT01737671 record still lists
NCT01737671 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 3 interventions - of which Leucovorin is the first listed.
NCT01737671 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01737671 about?
NCT01737671 is a clinical study titled "Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study". The goal of this clinical research study is to learn if it is safe to receive methotrexate through the fourth ventricle of the brain in patients with brain tumors. Methotrexate is designed to block cancer cells from dividing, which may slow or stop their growth and spread throughout the body. This ...
What is the current status of trial NCT01737671?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 7 participants. The study started on 2012-12-27. Estimated completion is 2018-01-11.
What interventions are being tested in trial NCT01737671?
The interventions under investigation include: Leucovorin (DRUG), Methotrexate (DRUG), Ommaya Reservoir (PROCEDURE).
Who is sponsoring clinical trial NCT01737671?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01737671's enrollment target sits among peer trials
7 1826th of 2000 higher than 156 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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