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NCT01725035 · ClinicalTrials.gov registry record
Hepatic De Novo Lipogenesis (DNL)in the Pathogenesis of Hepatic Steatosis in Obese Youth
A clinical trial, sponsored by Yale University.
- Completed
- Registry status
- 60
- Enrollment target
NCT01725035 is a clinical trial that has completed, run by Yale University. The registered enrollment target is 60 participants.
The verdict
NCT01725035 has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
Study Summary
Nonalcoholic Fatty Liver Disease (NAFLD) is becoming the most common cause of liver disease in pediatrics, but little is known about its pathophysiology in children. While studies in obese adults with hepatic steatosis have described an increased hepatic de novo lipogenesis (DNL) depending on the diet, there are no studies exploring the mechanisms by which excess hepatic triglycerides increases in obese youths, thus explaining the accompanying dyslipidemia and the metabolic syndrome. The central hypothesis of this study is that hepatic conversion of carbohydrates to lipid (DNL) is enhanced and associated with accumulation of excess liver fat, dyslipidemia and hepatic insulin resistance in obese youths with hepatic steatosis. The overall goal is to examine whether hepatic DNL is increased in obese youths with steatosis compared to matched controls without steatosis. Hypotheses: Hepatic conversion of carbohydrates to lipid (DNL) is enhanced and is associated with accumulation of excess liver fat, dyslipidemia and hepatic insulin resistance in obese youths with hepatic steatosis.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2010-12 |
| Est. Completion | 2022-08-10 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01725035
The ClinicalTrials.gov registry entry for NCT01725035 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01725035 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01725035 about?
NCT01725035 is a clinical study titled "Hepatic De Novo Lipogenesis (DNL)in the Pathogenesis of Hepatic Steatosis in Obese Youth". Nonalcoholic Fatty Liver Disease (NAFLD) is becoming the most common cause of liver disease in pediatrics, but little is known about its pathophysiology in children. While studies in obese adults with hepatic steatosis have described an increased hepatic de novo lipogenesis (DNL) depending on the di...
What is the current status of trial NCT01725035?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2010-12. Estimated completion is 2022-08-10.
Who is sponsoring clinical trial NCT01725035?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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