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NCT01715844 · ClinicalTrials.gov registry record · Phase 1
L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics
A Phase 1 study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT01715844 is a Phase 1 study that has completed, run by University of Pittsburgh. The registered enrollment target is 10 participants.
The verdict
NCT01715844, a Phase 1 study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
In people who develop asthma after the age of 12 and who are also overweigh, there can be an increased burden of asthma symptoms, more flare-ups, and poorly-controlled asthma when compared to normal weight asthmatics. Certain factors are more abundant in the blood of individuals who are obese. One such factor is derived from the metabolism of an amino acid found in your diet, which is known as L-arginine (Amino acids are most commonly known as the building blocks of proteins, the same as the proteins found in food). This factor is called asymmetric dimethylarginine or ADMA. The balance of L-arginine to ADMA may be important to the health of subjects with asthma. The balance between L-arginine and ADMA plays an important role in producing nitric oxide (NO) in the airways. NO is normally produced in the lung and plays a major role in maintaining airways open and functioning normally. Our research has shown that in subjects with asthma who are overweight and developed asthma later in life, the combination of low L-arginine and high ADMA, may lead to lower NO levels. We are asking participants in this study to take L-citrulline, which is converted to L-arginine by your body, as a supplement for a period of one week. We anticipate that L-citrulline will restore NO levels in the airways, by increasing the ratio of L-arginine to ADMA
Interventions
- DIETARY_SUPPLEMENT L-citrulline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2013-09-07 |
| Est. Completion | 2017-06-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01715844
The ClinicalTrials.gov registry entry for NCT01715844 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which L-citrulline is the first listed.
NCT01715844 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01715844 about?
NCT01715844 is a clinical study titled "L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics". In people who develop asthma after the age of 12 and who are also overweigh, there can be an increased burden of asthma symptoms, more flare-ups, and poorly-controlled asthma when compared to normal weight asthmatics. Certain factors are more abundant in the blood of individuals who are obese. One s...
What is the current status of trial NCT01715844?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2013-09-07. Estimated completion is 2017-06-01.
What interventions are being tested in trial NCT01715844?
The interventions under investigation include: L-citrulline (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01715844?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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