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NCT01682304 · ClinicalTrials.gov registry record
Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension
A clinical trial, sponsored by Ohio State University.
- Completed
- Registry status
- 12
- Enrollment target
NCT01682304: Completed study, sponsored by Ohio State University.
NCT01682304 is a clinical trial that has completed, run by Ohio State University. The registered enrollment target is 12 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01682304 has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- 12 participants
- Enrollment target
Study Summary
Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further, common patterns of differential DNA methylation were found in the common genes from placental tissue at time of birth in the same women after diagnosis with PE, suggesting that the epigenomic patterns that predict pregnancy-induced hypertension may also underlie the development of chronic hypertension years after. It is unknown whether aberrant DNA methylation in pregnancy-induced hypertension is the mechanism by which chronic hypertension develops in these women remote from pregnancy nor is it known if hypertension remote from PE is as responsive to therapeutic treatment of hypertension compared to women who develop hypertension without history of PE. The investigators plan to objectively test the central hypothesis and attain the objective of this project
Primary Outcome
Determine DNA methylatiion patterns in women with hypertension who have/have not had a prior diagnosis of preeclampsia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2012-05 |
| Est. Completion | 2014-03 |
What the finished NCT01682304 record still lists
NCT01682304 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 12 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01682304 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01682304 about?
NCT01682304 is a clinical study titled "Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension". Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further,...
What is the current status of trial NCT01682304?
This trial is currently completed. The enrollment target is 12 participants. The study started on 2012-05. Estimated completion is 2014-03.
Who is sponsoring clinical trial NCT01682304?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
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