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NCT01671605 · ClinicalTrials.gov registry record
Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation
A clinical trial, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- 103
- Enrollment target
NCT01671605 is a clinical trial that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 103 participants.
The verdict
NCT01671605 has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- 103 participants
- Enrollment target
Study Summary
There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent of serum lipoprotein levels as renal function declines. We propose to systematically examine scavenger receptors and cholesterol uptake as well as cholesterol transporters and efflux mechanisms in individuals with normal renal function, patients with moderate CKD. We further propose to determine if processed contributing to foam cell formation are related to the plasma lipid profile and if the relationship is modified by co-morbidities, such as diabetes, obesity, systemic inflammation which are common in this population and directly influence vascular integrity. These data will be critically important to understand when the abnormality starts and will provide crucial information.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2013-02 |
| Est. Completion | 2015-04 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01671605
The ClinicalTrials.gov registry entry for NCT01671605 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 103 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01671605 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01671605 about?
NCT01671605 is a clinical study titled "Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation". There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent ...
What is the current status of trial NCT01671605?
This trial is currently completed. The enrollment target is 103 participants. The study started on 2013-02. Estimated completion is 2015-04.
Who is sponsoring clinical trial NCT01671605?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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