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NCT01671605 · ClinicalTrials.gov registry record
Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation
A clinical trial, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- 103
- Enrollment target
NCT01671605: Completed study, sponsored by Vanderbilt University Medical Center.
NCT01671605 is a clinical trial that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 103 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01671605 has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- 103 participants
- Enrollment target
Study Summary
There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent of serum lipoprotein levels as renal function declines. We propose to systematically examine scavenger receptors and cholesterol uptake as well as cholesterol transporters and efflux mechanisms in individuals with normal renal function, patients with moderate CKD. We further propose to determine if processed contributing to foam cell formation are related to the plasma lipid profile and if the relationship is modified by co-morbidities, such as diabetes, obesity, systemic inflammation which are common in this population and directly influence vascular integrity. These data will be critically important to understand when the abnormality starts and will provide crucial information.
Primary Outcome
Cholesterol efflux. Baseline and outcome measurements are the same. The cholesterol efflux was measured once using HDL isolated from CKD and control patients. There was no intervention,this assessment was performed once in each group. The measurement of cholesterol efflux is performed by an in vitro assay in cultured cells. Cells are loaded with cholesterol and maintained for 72 hours. The media of the cultured cells is then changed and the new media contains HDL from CKD or control patients. In
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2013-02 |
| Est. Completion | 2015-04 |
What the finished NCT01671605 record still lists
NCT01671605 is an observational study that tracks outcomes without assigning an intervention. The registered 103 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01671605 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01671605 about?
NCT01671605 is a clinical study titled "Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation". There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent ...
What is the current status of trial NCT01671605?
This trial is currently completed. The enrollment target is 103 participants. The study started on 2013-02. Estimated completion is 2015-04.
Who is sponsoring clinical trial NCT01671605?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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