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NCT01669590 · ClinicalTrials.gov registry record
Nutrient Regulation of Amino Acid Transporters in Aging Human Skeletal Muscle
A clinical trial, sponsored by University of Utah.
- Completed
- Registry status
- 28
- Enrollment target
NCT01669590: Completed study, sponsored by University of Utah.
NCT01669590 is a clinical trial that has completed, run by University of Utah. The registered enrollment target is 28 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01669590 has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- 28 participants
- Enrollment target
Study Summary
The goal of the research project is to determine how aging and inactivity reduce the muscle anabolic effect of nutrients and lead to muscle and functional loss. The central hypothesis is that aging reduces mTORC1 signaling and the expression of skeletal muscle amino acid transporters in response to anabolic stimulation leading to reduced muscle adaptation to increased intracellular amino acid requirements. The investigators further hypothesize that inactivity exacerbates this effect with significant muscle and functional loss, and rehabilitation restores muscle signaling, metabolism and function to baseline values.
Primary Outcome
Muscle biopsies will be sampled from the vastus laterals before amino acid ingestion and then 1 and 3h after amino acid ingestion. Muscle biopsies will be processed using western blotting and gene expression to assess the expression of specific amino acid transporters. The investigators are interested in the change in expression of amino acid transporters in response to amino acid ingestion from baseline. The response before bed rest will be compared to after bed rest.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2011-12 |
| Est. Completion | 2016-09 |
What the finished NCT01669590 record still lists
NCT01669590 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 28 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01669590 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01669590 about?
NCT01669590 is a clinical study titled "Nutrient Regulation of Amino Acid Transporters in Aging Human Skeletal Muscle". The goal of the research project is to determine how aging and inactivity reduce the muscle anabolic effect of nutrients and lead to muscle and functional loss. The central hypothesis is that aging reduces mTORC1 signaling and the expression of skeletal muscle amino acid transporters in response to ...
What is the current status of trial NCT01669590?
This trial is currently completed. The enrollment target is 28 participants. The study started on 2011-12. Estimated completion is 2016-09.
Who is sponsoring clinical trial NCT01669590?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
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