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NCT01647282 · ClinicalTrials.gov registry record · Phase 4
Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients
A Phase 4 study of Moderate to Advanced Chronic Periodontitis, sponsored by University of Nebraska.
- Completed
- Registry status
- Phase 4
- Development phase
- 60
- Enrollment target
- 2
- Study locations
NCT01647282: Completed Phase 4 study of Moderate to Advanced Chronic Periodontitis, sponsored by University of Nebraska.
NCT01647282 is a Phase 4 study of Moderate to Advanced Chronic Periodontitis that has completed, run by University of Nebraska. The registered enrollment target is 60 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01647282, a Phase 4 study of Moderate to Advanced Chronic Periodontitis, has completed, sponsored by University of Nebraska.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 60 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis within a periodontal maintenance program.
Primary Outcome
Changes in interproximal bone height loss were measured over the course of 24 months in two groups; patients receiving scaling and root planing alone in a deep periodontal pocket and those receiving scaling and root planing as well as minocycline microspheres in a deep periodontal pocket. These changes in interproximal bone height loss (mm) were determined via bitewing radiographs taken at baseline and 24 months and measured as distance from the cemento-enamel junction to the alveolar bone. Chan
Conditions Studied
Interventions
- DRUG locally-applied minocycline HCl (1 mg)
- PROCEDURE scaling and root planing (Sc/RP)
Study Locations (2)
Nebraska
- University of Nebraska, College of Dentistry - Lincoln
- Creighton University School of Dentistry - Omaha
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2012-10-01 |
| Est. Completion | 2015-12-01 |
| Phase | Phase 4 |
What the finished NCT01647282 record still lists
NCT01647282 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Moderate to Advanced Chronic Periodontitis appearing as the primary indexed condition, and to 2 interventions - of which locally-applied minocycline HCl (1 mg) is the first listed.
NCT01647282 reports a single indexed study location in Nebraska.
Frequently Asked Questions
What is clinical trial NCT01647282 about?
NCT01647282 is a clinical study titled "Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients". The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis within a periodontal maintenance program.
What is the current status of trial NCT01647282?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 60 participants. The study started on 2012-10-01. Estimated completion is 2015-12-01.
What conditions does trial NCT01647282 study?
This clinical trial studies the following conditions: Moderate to Advanced Chronic Periodontitis.
What interventions are being tested in trial NCT01647282?
The interventions under investigation include: locally-applied minocycline HCl (1 mg) (DRUG), scaling and root planing (Sc/RP) (PROCEDURE).
Who is sponsoring clinical trial NCT01647282?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01647282 being conducted?
This trial has 2 study locations across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01647282's enrollment target sits among peer trials
60 1125th of 2000 higher than 800 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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