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NCT01643226 · ClinicalTrials.gov registry record · Phase 3
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
A Phase 3 study, sponsored by Glaukos Corporation.
- Completed
- Registry status
- Phase 3
- Development phase
- 230
- Enrollment target
NCT01643226: Completed Phase 3 study, sponsored by Glaukos Corporation.
NCT01643226 is a Phase 3 study that has completed, run by Glaukos Corporation. The registered enrollment target is 230 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01643226, a Phase 3 study, has completed, sponsored by Glaukos Corporation.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 230 participants
- Enrollment target
Study Summary
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression of, and/or reducing, maximum corneal curvature.
Interventions
- DRUG riboflavin solution
- DRUG placebo solution
- DEVICE KXL System
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 2012-07 |
| Est. Completion | 2016-09 |
| Phase | Phase 3 |
What the finished NCT01643226 record still lists
NCT01643226 is an interventional study that assigns participants to a tested intervention. The registered 230 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 3 interventions - of which riboflavin solution is the first listed.
NCT01643226 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01643226 about?
NCT01643226 is a clinical study titled "Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus". The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression of, and/or reducing, maximum corneal curvature.
What is the current status of trial NCT01643226?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 230 participants. The study started on 2012-07. Estimated completion is 2016-09.
What interventions are being tested in trial NCT01643226?
The interventions under investigation include: riboflavin solution (DRUG), placebo solution (DRUG), KXL System (DEVICE).
Who is sponsoring clinical trial NCT01643226?
This trial is sponsored by Glaukos Corporation, which has 33 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01643226's enrollment target sits among peer trials
230 1304th of 2000 higher than 692 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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