Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01628133 · ClinicalTrials.gov registry record
Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates
A clinical trial, sponsored by St. Louis University.
- Completed
- Registry status
- 25
- Enrollment target
NCT01628133 is a clinical trial that has completed, run by St. Louis University. The registered enrollment target is 25 participants.
The verdict
NCT01628133 has completed, sponsored by St. Louis University.
- COMPLETED
- Registry status
- 25 participants
- Enrollment target
Study Summary
The purpose of the study is to determine whether packed red blood cell (PRBC) transfusion affects intestinal blood flow of premature infants during feedings and if so, whether return of normal intestinal blood flow pattern occurs within 48 hours of blood transfusion. Abnormal intestinal responses to the feedings (insufficient postprandial blood flow increase in order to digest given feeding volume or overall decrease of intestinal blood flow) may predispose infants to feeding intolerance and to serious intestinal disease called necrotizing enterocolitis (NEC). Patent ductus arteriosus (PDA) is a relatively common heart condition found in young preterm infants that can lead to decreased blood flow in different organs, including intestines. Thus, the determination of the presence or absence of PDA is an important part of the study, since it can be a relevant confounding variable. In this study, the investigators will assess intestinal blood flow by using sonogram to measure velocity through the superior mesenteric artery (SMA), the artery supplying most of the intestine, both pre- and 45 minutes post feeding. The investigators will also use echocardiogram to determine the presence or absence of PDA. Each set of measurements will be done immediately before and after the transfusion, and again 24 and 48 hours after the transfusion. Specific Hypothesis: The investigators hypothesize that infants will have attenuated postprandial blood flow velocities in immediate posttransfusion state when compared to the pretransfusion values. The investigators further hypothesize that normal, pretransfusion postprandial blood flow velocities will be achieved 48 hrs after the blood transfusion.
Interventions
- PROCEDURE ultrasound
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2011-12 |
| Est. Completion | 2014-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01628133
The ClinicalTrials.gov registry entry for NCT01628133 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Louis University, which has 107 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which ultrasound is the first listed.
NCT01628133 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01628133 about?
NCT01628133 is a clinical study titled "Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates". The purpose of the study is to determine whether packed red blood cell (PRBC) transfusion affects intestinal blood flow of premature infants during feedings and if so, whether return of normal intestinal blood flow pattern occurs within 48 hours of blood transfusion. Abnormal intestinal responses t...
What is the current status of trial NCT01628133?
This trial is currently completed. The enrollment target is 25 participants. The study started on 2011-12. Estimated completion is 2014-01.
What interventions are being tested in trial NCT01628133?
The interventions under investigation include: ultrasound (PROCEDURE).
Who is sponsoring clinical trial NCT01628133?
This trial is sponsored by St. Louis University, which has 107 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.