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NCT01625130 · ClinicalTrials.gov registry record · NA
Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT01625130: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT01625130 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01625130, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
Purpose: To determine if modulation of NRF2 with a Sulforaphane enriched supplement modifies responses to O3. Participants: Recruitment of up to 70 healthy volunteers, ages 18-50, for completion of 36 volunteers. Procedures: This is a randomized, placebo controlled 2x2 crossover study of treatment with an NRF2 modifier versus placebo in healthy volunteers which will examine airway inflammation before and 4 hours after a 2 hour 0.4 ppm O3 exposure. Participants will be randomized to received either the NRF2 modifier, SFN oral supplement (i.e. broccoli sprout shake), or placebo (alfalfa shake) for 3 days followed by a 0.4 ppm O3 exposure for 2 hours. At least 2 weeks later subjects will return for a 2nd supplementation treatment (using the alternative supplement to that provided initially) followed by an ozone exposure identical to the initial one.
Primary Outcome
Induced sputum will be collected and % neutrophils will be measured after each exposure and will be compared to baseline and to each other.
Interventions
- DIETARY_SUPPLEMENT Broccoli sprout homogenate
- DIETARY_SUPPLEMENT alfalfa sprout homogenate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2013-10 |
| Est. Completion | 2015-06 |
| Phase | NA |
What the finished NCT01625130 record still lists
NCT01625130 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Broccoli sprout homogenate is the first listed.
NCT01625130 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01625130 about?
NCT01625130 is a clinical study titled "Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2". Purpose: To determine if modulation of NRF2 with a Sulforaphane enriched supplement modifies responses to O3. Participants: Recruitment of up to 70 healthy volunteers, ages 18-50, for completion of 36 volunteers. Procedures: This is a randomized, placebo controlled 2x2 crossover study of treatment w...
What is the current status of trial NCT01625130?
This trial is currently completed. It is a NA study. The enrollment target is 16 participants. The study started on 2013-10. Estimated completion is 2015-06.
What interventions are being tested in trial NCT01625130?
The interventions under investigation include: Broccoli sprout homogenate (DIETARY_SUPPLEMENT), alfalfa sprout homogenate (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01625130?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01625130's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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