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NCT01578083 · ClinicalTrials.gov registry record
Chemotherapy-Induced Cognitive Impairment
A clinical trial, sponsored by Jay F. Piccirillo, MD.
- Completed
- Registry status
- 28
- Enrollment target
NCT01578083: Completed study, sponsored by Jay F. Piccirillo, MD.
NCT01578083 is a clinical trial that has completed, run by Jay F. Piccirillo, MD. The registered enrollment target is 28 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01578083 has completed, sponsored by Jay F. Piccirillo, MD.
- COMPLETED
- Registry status
- 28 participants
- Enrollment target
Study Summary
The investigators overall research hypothesis is that systemic chemotherapy induces structural changes in the white matter of the brain as demonstrated with Diffusion Tensor Imaging (DTI) and functional changes in well-defined cortical neural networks as demonstrated by resting-state functional connectivity MRI (rs-fcMRI). The investigators believe these structural and functional changes are responsible for the cognitive symptoms associated with chemotherapy-induced cognitive impairment (CICI). The Specific Aim for this study is: To assess the impact of chemotherapy on structural white matter as defined by DTI and functional cognitive networks as defined by rs-fcMRI by comparing a sample of breast cancer survivors with self-reported CICI to breast cancer survivors without CICI. Hypothesis: Post-chemotherapy breast cancer patients with self-reported CICI will have abnormal structural connections characterized by DTI-defined disruptions in fractional anisotropy (FA) and mean diffusivity (MD) and abnormal functional connectivity characterized by rs-fcMRI-defined disruptions in cognitive networks when compared to patients without self-reported CICI.
Primary Outcome
As compared with the controls, the breast cancer patients will show decreased fractional anisotropy (FA) in the frontal and temporal white matter (WM) tracts and.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2012-04 |
| Est. Completion | 2012-12 |
What the finished NCT01578083 record still lists
NCT01578083 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 28 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01578083 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01578083 about?
NCT01578083 is a clinical study titled "Chemotherapy-Induced Cognitive Impairment". The investigators overall research hypothesis is that systemic chemotherapy induces structural changes in the white matter of the brain as demonstrated with Diffusion Tensor Imaging (DTI) and functional changes in well-defined cortical neural networks as demonstrated by resting-state functional conn...
What is the current status of trial NCT01578083?
This trial is currently completed. The enrollment target is 28 participants. The study started on 2012-04. Estimated completion is 2012-12.
Who is sponsoring clinical trial NCT01578083?
This trial is sponsored by Jay F. Piccirillo, MD, which has 2 total clinical trials registered on ClinicalTrials.gov.
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