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NCT01557920 · ClinicalTrials.gov registry record · Phase 4
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
A Phase 4 study, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Phase 4
- Development phase
- 18
- Enrollment target
NCT01557920: Completed Phase 4 study, sponsored by Massachusetts General Hospital.
NCT01557920 is a Phase 4 study that has completed, run by Massachusetts General Hospital. The registered enrollment target is 18 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01557920, a Phase 4 study, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 18 participants
- Enrollment target
Study Summary
The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle. Additionally, the investigators hypothesize that, under increased carbon dioxide concentrations of the air inhaled, the upper airway will be less likely to collapse under anesthesia and there will be increased activity in the tongue muscle under both propofol and sevoflurane, when compared to breathing normal concentrations of carbon dioxide, as in room air. Furthermore the investigators hypothesize that anesthesia disrupt the breathing swallow coordination, an effect additionally altered by increased carbon dioxide through increased respiratory drive.
Primary Outcome
Upper airway closing pressure will be measured during steady state anesthesia as well as during carbon dioxide reversal.
Interventions
- DRUG Sevoflurane
- DRUG Propofol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2013-01 |
| Est. Completion | 2014-03 |
| Phase | Phase 4 |
What the finished NCT01557920 record still lists
NCT01557920 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Sevoflurane is the first listed.
NCT01557920 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01557920 about?
NCT01557920 is a clinical study titled "The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects". The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle. Additionally, the investigators hypothesize that, under increased carbon dioxide concentrations of the air inhaled, the upper airw...
What is the current status of trial NCT01557920?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 18 participants. The study started on 2013-01. Estimated completion is 2014-03.
What interventions are being tested in trial NCT01557920?
The interventions under investigation include: Sevoflurane (DRUG), Propofol (DRUG).
Who is sponsoring clinical trial NCT01557920?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01557920's enrollment target sits among peer trials
18 1842nd of 2000 higher than 147 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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