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NCT01555554 · ClinicalTrials.gov registry record · Phase 4
Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
A Phase 4 study, sponsored by University of California, San Francisco.
- Terminated
- Registry status
- Phase 4
- Development phase
- 59
- Enrollment target
NCT01555554 is a Phase 4 study that was terminated before completion, run by University of California, San Francisco. The registered enrollment target is 59 participants.
The verdict
NCT01555554, a Phase 4 study, was terminated before completion, sponsored by University of California, San Francisco.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 59 participants
- Enrollment target
Study Summary
Understanding what treatments may facilitate perioperative care of Veterans with posttraumatic stress disorder (PTSD) is of great importance to the U.S. health care system. Patients with PTSD are characterized by elevated central nervous system catecholamine concentrations and exaggerated and prolonged adrenergic responses to stress stimuli. At present, there are no data on the effects of perioperative beta blocker therapy in patients with PTSD, despite the rising significance of PTSD in Veteran populations. This prospective, double-blind study proposes to randomize 150 Veterans with PTSD scheduled for orthopedic, thoracic or vascular surgery at the San Francisco VA Medical Center to either a 14-day course of propranolol or placebo. This study will then follow these Veterans for a one-year period to evaluate the effects of the intervention on Veterans' surgical outcomes. The investigators hypothesize that patients with PTSD randomized to the propranolol group will demonstrate a reduced incidence of perioperative and postoperative morbidity and mortality.
Interventions
- OTHER Placebo
- DRUG Propranolol Hydrochloride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2012-05 |
| Est. Completion | 2019-06 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01555554
The ClinicalTrials.gov registry entry for NCT01555554 describes a study currently listed as terminated, categorized as Phase 4. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT01555554 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01555554 about?
NCT01555554 is a clinical study titled "Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)". Understanding what treatments may facilitate perioperative care of Veterans with posttraumatic stress disorder (PTSD) is of great importance to the U.S. health care system. Patients with PTSD are characterized by elevated central nervous system catecholamine concentrations and exaggerated and prolo...
What is the current status of trial NCT01555554?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 59 participants. The study started on 2012-05. Estimated completion is 2019-06.
What interventions are being tested in trial NCT01555554?
The interventions under investigation include: Placebo (OTHER), Propranolol Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT01555554?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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