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NCT01550705 · ClinicalTrials.gov registry record · NA
Effect of Isoniazid on Protoporphyrin Levels in Erythropoietic Protoporphyria
A NA study, sponsored by University of Utah.
- Terminated
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT01550705 is a NA study that was terminated before completion, run by University of Utah. The registered enrollment target is 11 participants.
The verdict
NCT01550705, a NA study, was terminated before completion, sponsored by University of Utah.
- TERMINATED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
In erythropoietic protoporphyria there is an accumulation of protoporphyrin IX (PPIX) in the plasma and liver. The reason it builds up is either the last step to make heme, insertion of iron into PPIX, is rate limiting or there is an increase in activity in the first step in the heme pathway. It may be possible to decrease the amount of PPIX made and see a decrease in symptoms. The first step to make heme is the key step in the pathway and it uses vitamin B6 as a cofactor. If the investigators can limit the amount of vitamin B6 the investigators can possibly reduce the activity of this rate limiting step. With decreased activity of the enzyme it may be possible for the body to utilize all the PPIX that is made so that none builds up.
Interventions
- DRUG Isoniazid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2012-03 |
| Est. Completion | 2015-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01550705
The ClinicalTrials.gov registry entry for NCT01550705 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Utah, which has 818 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Isoniazid is the first listed.
NCT01550705 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01550705 about?
NCT01550705 is a clinical study titled "Effect of Isoniazid on Protoporphyrin Levels in Erythropoietic Protoporphyria". In erythropoietic protoporphyria there is an accumulation of protoporphyrin IX (PPIX) in the plasma and liver. The reason it builds up is either the last step to make heme, insertion of iron into PPIX, is rate limiting or there is an increase in activity in the first step in the heme pathway. It ma...
What is the current status of trial NCT01550705?
This trial is currently terminated. It is a NA study. The enrollment target is 11 participants. The study started on 2012-03. Estimated completion is 2015-12.
What interventions are being tested in trial NCT01550705?
The interventions under investigation include: Isoniazid (DRUG).
Who is sponsoring clinical trial NCT01550705?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
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