Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01537393 · ClinicalTrials.gov registry record · Phase 4
Cornea Preservation Time Study
A Phase 4 study, sponsored by Case Western Reserve University.
- Completed
- Registry status
- Phase 4
- Development phase
- 1,174
- Enrollment target
NCT01537393: Completed Phase 4 study, sponsored by Case Western Reserve University.
NCT01537393 is a Phase 4 study that has completed, run by Case Western Reserve University. The registered enrollment target is 1,174 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (127% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01537393, a Phase 4 study, has completed, sponsored by Case Western Reserve University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 1,174 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if the 3-year graft failure rate following endothelial keratoplasty performed with donor corneas with a preservation time of 8 to 14 days is non-inferior to the failure rate when donor corneas with a preservation time of 7 or fewer days are used.
Primary Outcome
Graft failure, defined as the occurrence of one of the following within 3 years of surgery: * Regrafting of the study eye for any reason * Cornea which remains cloudy without clearing, according to the following: 1. cloudy cornea on the first postoperative day which does not clear within 8 weeks OR 2. cloudy cornea which was initially clear postoperatively but becomes and remains cloudy for 3 months without clearing.
Interventions
- BIOLOGICAL Cornea tissue transplant
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,174 participants |
| Start Date | 2012-04-16 |
| Est. Completion | 2017-06-30 |
| Phase | Phase 4 |
What the finished NCT01537393 record still lists
NCT01537393 is an interventional study that assigns participants to a tested intervention. Its 1,174 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (127% higher).
The record links to 0 conditions, and to 1 intervention - of which Cornea tissue transplant is the first listed.
NCT01537393 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01537393 about?
NCT01537393 is a clinical study titled "Cornea Preservation Time Study". The purpose of this study is to determine if the 3-year graft failure rate following endothelial keratoplasty performed with donor corneas with a preservation time of 8 to 14 days is non-inferior to the failure rate when donor corneas with a preservation time of 7 or fewer days are used.
What is the current status of trial NCT01537393?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 1,174 participants. The study started on 2012-04-16. Estimated completion is 2017-06-30.
What interventions are being tested in trial NCT01537393?
The interventions under investigation include: Cornea tissue transplant (BIOLOGICAL).
Who is sponsoring clinical trial NCT01537393?
This trial is sponsored by Case Western Reserve University, which has 141 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01537393's enrollment target sits among peer trials
1,174 63rd of 2000 higher than 1,938 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04275557 · 1,174 participants
Using Radiogenomics to Predict Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas
- NCT06133322 · 1,176 participants · NA
Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED)
- NCT05688436 · 1,178 participants
A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies
- NCT06931275 · 1,178 participants · NA
Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI