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COMPLETED Phase 2

A Study of Ramucirumab (IMC-1121B) and Paclitaxel in Participants With Solid Tumors

NCT01515306 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to investigate whether there are no clinically significant pharmacokinetic effects of concomitant ramucirumab (IMC-1121B) on paclitaxel by investigating the pharmacokinetics (PK) of each in participants with advanced malignant solid tumors. Part A of this study will investigate the potential of concomitant ramucirumab (IMC-1121B) to affect the pharmacokinetics of paclitaxel. Part B of this study will investigate the pharmacokinetics of ramucirumab (IMC-1121B) as monotherapy.

Conditions Studied

Interventions

  • DRUG paclitaxel
  • BIOLOGICAL ramucirumab (IMC-1121B)

Study Locations (6)

Michigan

  • ImClone Investigational Site — Ann Arbor
  • ImClone Investigational Site — Detroit

New Jersey

  • ImClone Investigational Site — New Brunswick

Ohio

  • ImClone Investigational Site — Cleveland

Pennsylvania

  • ImClone Investigational Site — Philadelphia

Washington

  • ImClone Investigational Site — Seattle

Trial Details

FieldValue
Enrollment Target 48 participants
Start Date 2012-07-19
Est. Completion 2021-02-22
Phase Phase 2

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01515306

The ClinicalTrials.gov registry entry for NCT01515306 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Malignant Solid Tumor appearing as the primary indexed condition, and to 2 interventions — of which paclitaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01515306 reports 6 study locations spanning 5 distinct geographic areas — top geographies include Michigan, New Jersey, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01515306 about?

NCT01515306 is a clinical study titled "A Study of Ramucirumab (IMC-1121B) and Paclitaxel in Participants With Solid Tumors". The purpose of this study is to investigate whether there are no clinically significant pharmacokinetic effects of concomitant ramucirumab (IMC-1121B) on paclitaxel by investigating the pharmacokinetics (PK) of each in participants with advanced malignant solid tumors. Part A of this study will inv...

What is the current status of trial NCT01515306?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2012-07-19. Estimated completion is 2021-02-22.

What conditions does trial NCT01515306 study?

This clinical trial studies the following conditions: Malignant Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01515306?

The interventions under investigation include: paclitaxel (DRUG), ramucirumab (IMC-1121B) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01515306?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01515306 being conducted?

This trial has 6 study locations across Michigan, New Jersey, Ohio, Pennsylvania, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial