Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01501929 · ClinicalTrials.gov registry record · Phase 4
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
A Phase 4 study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 32
- Enrollment target
NCT01501929: Completed Phase 4 study, sponsored by University of Texas Southwestern Medical Center.
NCT01501929 is a Phase 4 study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 32 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01501929, a Phase 4 study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 32 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative stress or increased endothelial nitric oxide synthase (eNOS) expression in humans.
Primary Outcome
Endothelial cell (EC) was collected after a 20-guage angiocatheter was inserted into the contralateral forearm vein under sterile conditions. Three J-shaped vascular guidewires (St. Jude, St. Paul, MN) were advanced sequentially into the vein up to 10 cm. Endothelial cells were collected by gentle abrasion and placed into a dissociation buffer (0.5% bovine serum albumin, 2mM EDTA, and 100 ug/ml heparin in PBS). Endothelial cells were recovered from the tips of guide wires by repeated washing int
Interventions
- DRUG Nebivolol
- DRUG Metoprolol succinate
- PROCEDURE Non-invasive measurement of Cardiac Output (CO)
- PROCEDURE Endothelial cell collection
- PROCEDURE Microvascular perfusion assessment using Definity
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2010-08 |
| Est. Completion | 2015-12 |
| Phase | Phase 4 |
What the finished NCT01501929 record still lists
NCT01501929 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 5 interventions - of which Nebivolol is the first listed.
NCT01501929 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01501929 about?
NCT01501929 is a clinical study titled "Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients". The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative stress or increased endothelial nitric oxide synthase (eNOS) expression i...
What is the current status of trial NCT01501929?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 32 participants. The study started on 2010-08. Estimated completion is 2015-12.
What interventions are being tested in trial NCT01501929?
The interventions under investigation include: Nebivolol (DRUG), Metoprolol succinate (DRUG), Non-invasive measurement of Cardiac Output (CO) (PROCEDURE), Endothelial cell collection (PROCEDURE), Microvascular perfusion assessment using Definity (PROCEDURE).
Who is sponsoring clinical trial NCT01501929?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01501929's enrollment target sits among peer trials
32 1534th of 2000 higher than 457 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02445781 · 32 participants · Early Phase 1
Differing Levels of Hypoglycemia
- NCT02792270 · 32 participants · NA
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
- NCT03068910 · 32 participants · Early Phase 1
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
- NCT03208868 · 32 participants · NA
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia