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NCT01496846 · ClinicalTrials.gov registry record · Phase 4
Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
A Phase 4 study of Irreversible Pulpitis, sponsored by University of Michigan.
- Completed
- Registry status
- Phase 4
- Development phase
- 201
- Enrollment target
- 1
- Study location
NCT01496846: Completed Phase 4 study of Irreversible Pulpitis, sponsored by University of Michigan.
NCT01496846 is a Phase 4 study of Irreversible Pulpitis that has completed, run by University of Michigan. The registered enrollment target is 201 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (61% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01496846, a Phase 4 study of Irreversible Pulpitis, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 201 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this trial is to study the ability of a frequently used dental anesthetic (articaine) to achieve complete numbness of a diseased tooth with the most commonly used injection technique in the lower jaw (inferior alveolar nerve block: IANB). If this technique fails, a commonly used supplemental (SUP) technique with one of two possible dental anesthetics (lidocaine or articaine) will be given to evaluate the success/failure of complete numbness between the two anesthetics. Standardized administration of anesthesia is provided by controlled delivery using Midwest Comfort Control Syringe. The investigators hypothesize that supplemental infiltration anesthesia with articaine will give the same success rate as lidocaine in achieving complete pulpal anesthesia in mandibular molars with irreversible pulpits. This study consisted of two periods of patient enrollment, treatment and data collection: Part I: 101 subjects; Part II: 100 subjects.
Primary Outcome
Following an unsuccessful IANB, supplemental infiltration anesthesia with either articaine or lidocaine was given to achieve complete pulpal anesthesia
Conditions Studied
Interventions
- DRUG IANB Articaine
- DRUG SUP Articaine
- DRUG SUP Lidocaine
Study Locations (1)
Michigan
- University of Michigan, School of Dentistry Clinics - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 201 participants |
| Start Date | 2011-09 |
| Est. Completion | 2016-02 |
| Phase | Phase 4 |
What the finished NCT01496846 record still lists
NCT01496846 is an interventional study that assigns participants to a tested intervention. The registered 201 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (61% lower).
The record links to 1 condition, with Irreversible Pulpitis appearing as the primary indexed condition, and to 3 interventions - of which IANB Articaine is the first listed.
NCT01496846 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT01496846 about?
NCT01496846 is a clinical study titled "Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars". The purpose of this trial is to study the ability of a frequently used dental anesthetic (articaine) to achieve complete numbness of a diseased tooth with the most commonly used injection technique in the lower jaw (inferior alveolar nerve block: IANB). If this technique fails, a commonly used suppl...
What is the current status of trial NCT01496846?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 201 participants. The study started on 2011-09. Estimated completion is 2016-02.
What conditions does trial NCT01496846 study?
This clinical trial studies the following conditions: Irreversible Pulpitis.
What interventions are being tested in trial NCT01496846?
The interventions under investigation include: IANB Articaine (DRUG), SUP Articaine (DRUG), SUP Lidocaine (DRUG).
Who is sponsoring clinical trial NCT01496846?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01496846 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Irreversible Pulpitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01496846's enrollment target sits among peer trials
201 406th of 2000 higher than 1,594 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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