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NCT01489930 · ClinicalTrials.gov registry record · NA
Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
A NA study, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 67
- Enrollment target
NCT01489930: Completed NA study, sponsored by Mayo Clinic.
NCT01489930 is a NA study that has completed, run by Mayo Clinic. The registered enrollment target is 67 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01489930, a NA study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 67 participants
- Enrollment target
Study Summary
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (\> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training. Hypotheses. 1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program 2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age 3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program 4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
Primary Outcome
The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.
Interventions
- BEHAVIORAL Resistance exercise
- BEHAVIORAL Endurance exercise
- BEHAVIORAL Control/Combined training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 67 participants |
| Start Date | 2008-05 |
| Est. Completion | 2011-02 |
| Phase | NA |
What the finished NCT01489930 record still lists
NCT01489930 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 67 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 3 interventions - of which Resistance exercise is the first listed.
NCT01489930 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01489930 about?
NCT01489930 is a clinical study titled "Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults". Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging populati...
What is the current status of trial NCT01489930?
This trial is currently completed. It is a NA study. The enrollment target is 67 participants. The study started on 2008-05. Estimated completion is 2011-02.
What interventions are being tested in trial NCT01489930?
The interventions under investigation include: Resistance exercise (BEHAVIORAL), Endurance exercise (BEHAVIORAL), Control/Combined training (BEHAVIORAL).
Who is sponsoring clinical trial NCT01489930?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01489930's enrollment target sits among peer trials
67 1139th of 2000 higher than 862 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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