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NCT01483690 · ClinicalTrials.gov registry record · Phase 1
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL
A Phase 1 study, sponsored by Therapeutic Advances in Childhood Leukemia Consortium.
- Terminated
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT01483690: Clinical Trial Phase 1 study, sponsored by Therapeutic Advances in Childhood Leukemia Consortium.
NCT01483690 is a Phase 1 study that was terminated before completion, run by Therapeutic Advances in Childhood Leukemia Consortium. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01483690, a Phase 1 study, was terminated before completion, sponsored by Therapeutic Advances in Childhood Leukemia Consortium.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
This is a pilot study using decitabine and vorinostat before and during chemotherapy with vincristine, dexamethasone, mitoxantrone, and peg-asparaginase in pediatric patients with acute lymphoblastic leukemia (ALL).
Primary Outcome
To evaluate the side effects of giving decitabine and vorinostat before and during chemotherapy using the standard drugs vincristine, dexamethasone, PEG-asparaginase and mitoxantrone.
Interventions
- DRUG Decitabine
- DRUG Dexamethasone
- DRUG Vincristine
- DRUG Mitoxantrone
- DRUG Vorinostat
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2011-12 |
| Est. Completion | 2015-07-31 |
| Phase | Phase 1 |
Why NCT01483690 stopped before completion
NCT01483690 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 5 interventions - of which Decitabine is the first listed.
NCT01483690 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01483690 about?
NCT01483690 is a clinical study titled "A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL". This is a pilot study using decitabine and vorinostat before and during chemotherapy with vincristine, dexamethasone, mitoxantrone, and peg-asparaginase in pediatric patients with acute lymphoblastic leukemia (ALL).
What is the current status of trial NCT01483690?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2011-12. Estimated completion is 2015-07-31.
What interventions are being tested in trial NCT01483690?
The interventions under investigation include: Decitabine (DRUG), Dexamethasone (DRUG), Vincristine (DRUG), Mitoxantrone (DRUG), Vorinostat (DRUG).
Who is sponsoring clinical trial NCT01483690?
This trial is sponsored by Therapeutic Advances in Childhood Leukemia Consortium, which has 19 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01483690's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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