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NCT01477164 · ClinicalTrials.gov registry record · NA
Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
A NA study, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 72
- Enrollment target
NCT01477164: Completed NA study, sponsored by Mayo Clinic.
NCT01477164 is a NA study that has completed, run by Mayo Clinic. The registered enrollment target is 72 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01477164, a NA study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
Study Summary
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins). Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people. Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people. Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.
Primary Outcome
The investigators will determine the rate of incorporation of stable isotope amino acid tracers in skeletal muscle proteins during several hours of rest. The measurement will be an average resting muscle protein synthesis rate (% new muscle protein per hour) and will be performed at baseline and following 12 weeks of exercise training.
Interventions
- BEHAVIORAL Combined
- BEHAVIORAL High intensity aerobic exercise
- BEHAVIORAL Resistance exercise training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2011-11 |
| Est. Completion | 2017-03 |
| Phase | NA |
What the finished NCT01477164 record still lists
NCT01477164 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 3 interventions - of which Combined is the first listed.
NCT01477164 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01477164 about?
NCT01477164 is a clinical study titled "Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults". Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine...
What is the current status of trial NCT01477164?
This trial is currently completed. It is a NA study. The enrollment target is 72 participants. The study started on 2011-11. Estimated completion is 2017-03.
What interventions are being tested in trial NCT01477164?
The interventions under investigation include: Combined (BEHAVIORAL), High intensity aerobic exercise (BEHAVIORAL), Resistance exercise training (BEHAVIORAL).
Who is sponsoring clinical trial NCT01477164?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01477164's enrollment target sits among peer trials
72 1089th of 2000 higher than 899 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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