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NCT01467466 · ClinicalTrials.gov registry record · Phase 3
Prevention of Serious Adverse Events Following Angiography
A Phase 3 study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- Phase 3
- Development phase
- 5,177
- Enrollment target
NCT01467466: Completed Phase 3 study, sponsored by VA Office of Research and Development.
NCT01467466 is a Phase 3 study that has completed, run by VA Office of Research and Development. The registered enrollment target is 5,177 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (571% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01467466, a Phase 3 study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 5,177 participants
- Enrollment target
Study Summary
The purpose of this research study is to compare the effectiveness of intravenous isotonic sodium bicarbonate with intravenous isotonic sodium chloride and oral N-acetylcysteine (NAC) with oral placebo for the prevention of serious adverse outcomes following angiographic procedures in high-risk patients.
Primary Outcome
Death will be based on medical record and/or vital status registry documentation Need for acute dialysis will be defined as the initiation of any modality of renal replacement (intermittent hemodialysis, peritoneal dialysis, continuous renal replacement therapy, or sustained low-efficiency dialysis) Persistent decline in kidney function will be defined as an increase in serum creatinine of at least 50% from the baseline value collected pre-angiography to the measurement taken 90 days following t
Interventions
- DRUG Placebo
- DRUG N-acetylcysteine
- DRUG IV isotonic saline
- DRUG IV isotonic bicarbonate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5,177 participants |
| Start Date | 2013-10-07 |
| Est. Completion | 2017-10-17 |
| Phase | Phase 3 |
What the finished NCT01467466 record still lists
NCT01467466 is an interventional study that assigns participants to a tested intervention. Its 5,177 participants enrollment target places it among the larger protocols in the corpus, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (571% higher).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT01467466 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01467466 about?
NCT01467466 is a clinical study titled "Prevention of Serious Adverse Events Following Angiography". The purpose of this research study is to compare the effectiveness of intravenous isotonic sodium bicarbonate with intravenous isotonic sodium chloride and oral N-acetylcysteine (NAC) with oral placebo for the prevention of serious adverse outcomes following angiographic procedures in high-risk pati...
What is the current status of trial NCT01467466?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 5,177 participants. The study started on 2013-10-07. Estimated completion is 2017-10-17.
What interventions are being tested in trial NCT01467466?
The interventions under investigation include: Placebo (DRUG), N-acetylcysteine (DRUG), IV isotonic saline (DRUG), IV isotonic bicarbonate (DRUG).
Who is sponsoring clinical trial NCT01467466?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01467466's enrollment target sits among peer trials
5,177 47th of 2000 higher than 1,954 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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