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NCT01456208 · ClinicalTrials.gov registry record
Genetic Mechanisms in Human Hypertension
A clinical trial, sponsored by Brigham and Women's Hospital.
- Terminated
- Registry status
- 150
- Enrollment target
NCT01456208: Clinical Trial study, sponsored by Brigham and Women's Hospital.
NCT01456208 is a clinical trial that was terminated before completion, run by Brigham and Women's Hospital. The registered enrollment target is 150 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01456208 was terminated before completion, sponsored by Brigham and Women's Hospital.
- TERMINATED
- Registry status
- 150 participants
- Enrollment target
Study Summary
Thank you for your interest in the investigators Genetics and Blood Pressure Research Study. The National Institutes of Health are sponsoring us to investigate why patients develop high blood pressure, atherosclerosis (hardening of the arteries), and heart disease. There are two parts of the investigators research program. The first part is a screening visit. At this visit you will be given a brief physical exam and will be asked questions concerning your medical history. During the same visit you will have your blood drawn for routine screening and to prepare DNA for genetic testing. You will also be asked to collect a urine sample for routine screening. If the doctor finds that you are a healthy candidate you will be invited to participate in the second part of the study. During Phase II, the investigators will perform physiological tests after you are placed on a low salt diet and again after you are placed on a high salt diet. If you are on blood pressure medication, it may be necessary to discontinue taking your present medication for up to three months before beginning the study. Patients discontinuing their current blood pressure medication may be placed on a different blood pressure medication during this washout period if necessary to maintain blood pressure at pre-study levels. The investigators will take you off all medications at about two weeks prior to your scheduled in-patient study (overnight visits). Once your blood pressure medications are discontinued, you will be closely monitored to make sure you do not encounter any difficulty. If you do not own a home blood pressure monitor, the investigators will provide one for you to use during the study so that you can keep a daily record of your blood pressure readings. The investigators will ask you to call us every three days to report your blood pressure readings. Less than 20% of patients have any significant increase in their blood pressure during this short time off of therapy. After you have stop
Primary Outcome
1. Frequency of AGT minor allele homozygotics in non-modulating hypertension. 2. Frequency of ALAP minor allele homozygotics in non-modulating hypertension.
Interventions
- DRUG Norepinephrine
- DRUG Angiotensin II
- DRUG Para-aminohippuric Acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 1999-10 |
| Est. Completion | 2020-06 |
Why NCT01456208 stopped before completion
NCT01456208 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 3 interventions - of which Norepinephrine is the first listed.
NCT01456208 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01456208 about?
NCT01456208 is a clinical study titled "Genetic Mechanisms in Human Hypertension". Thank you for your interest in the investigators Genetics and Blood Pressure Research Study. The National Institutes of Health are sponsoring us to investigate why patients develop high blood pressure, atherosclerosis (hardening of the arteries), and heart disease. There are two parts of the investi...
What is the current status of trial NCT01456208?
This trial is currently terminated. The enrollment target is 150 participants. The study started on 1999-10. Estimated completion is 2020-06.
What interventions are being tested in trial NCT01456208?
The interventions under investigation include: Norepinephrine (DRUG), Angiotensin II (DRUG), Para-aminohippuric Acid (DRUG).
Who is sponsoring clinical trial NCT01456208?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
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