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NCT01446874 · ClinicalTrials.gov registry record · Phase 2
Prevention of Post-operative Pneumonia (POPP)
A Phase 2 study, sponsored by Washington University School of Medicine.
- Terminated
- Registry status
- Phase 2
- Development phase
- 150
- Enrollment target
NCT01446874: Clinical Trial Phase 2 study, sponsored by Washington University School of Medicine.
NCT01446874 is a Phase 2 study that was terminated before completion, run by Washington University School of Medicine. The registered enrollment target is 150 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01446874, a Phase 2 study, was terminated before completion, sponsored by Washington University School of Medicine.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 150 participants
- Enrollment target
Study Summary
Postoperative pneumonia is a major complication in patients undergoing thoracic surgery. It leads to considerable morbidity and contributes to perioperative morbidity. There is evidence in literature that supports the use of strategies for improved oral hygiene and specialized endotracheal tubes in preventing ventilator associated pneumonia (VAP) in mechanically ventilated patients. This study aims at utilizing a combination of these interventions in the perioperative period in patients undergoing planned thoracic surgical procedures.
Primary Outcome
Patients will be considered to have postoperative pneumonia if they meet three of the following criteria within 30 days after surgery; 1. Fever (Temperature \>38.2 C) 2. Leucocytosis (WBC\>12,000/cu mm) 3. New infiltrate on chest X-ray 4. Positive sputum or bronchial culture 5. Treatment with antibiotics These criteria are utilized by the national Society of Thoracic Surgeons' database.
Interventions
- DRUG 0.12% chlorhexidine solution
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2011-09-22 |
| Est. Completion | 2015-12-13 |
| Phase | Phase 2 |
Why NCT01446874 stopped before completion
NCT01446874 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 1 intervention - of which 0.12% chlorhexidine solution is the first listed.
NCT01446874 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01446874 about?
NCT01446874 is a clinical study titled "Prevention of Post-operative Pneumonia (POPP)". Postoperative pneumonia is a major complication in patients undergoing thoracic surgery. It leads to considerable morbidity and contributes to perioperative morbidity. There is evidence in literature that supports the use of strategies for improved oral hygiene and specialized endotracheal tubes in ...
What is the current status of trial NCT01446874?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2011-09-22. Estimated completion is 2015-12-13.
What interventions are being tested in trial NCT01446874?
The interventions under investigation include: 0.12% chlorhexidine solution (DRUG).
Who is sponsoring clinical trial NCT01446874?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01446874's enrollment target sits among peer trials
150 455th of 2000 higher than 1,510 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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