Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT01442090 · ClinicalTrials.gov registry record · Phase 2

Study of GDC-0980 Versus Everolimus in Participants With Metastatic Renal Cell Carcinoma Who Have Progressed on or Following Vascular Endothelial Growth Factor- (VEGF) Targeted Therapy

A Phase 2 study, sponsored by Genentech.

Completed
Registry status
Phase 2
Development phase
85
Enrollment target

NCT01442090: Completed Phase 2 study, sponsored by Genentech.

NCT01442090 is a Phase 2 study that has completed, run by Genentech. The registered enrollment target is 85 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (36% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT01442090, a Phase 2 study, has completed, sponsored by Genentech.

COMPLETED
Registry status
Phase 2
Development phase
85 participants
Enrollment target

Study Summary

Study PIM4973g is a multicenter, international, open-label Phase II trial. Participants with metastatic renal cell carcinoma who have progressed on or after VEGF targeted therapy will be randomized in 1:1 to two groups either to receive daily GDC-0980 or everolimus orally.

Interventions

  • DRUG Everolimus
  • DRUG GDC-0980

Trial Details

FieldValue
Enrollment Target 85 participants
Start Date 2011-10
Est. Completion 2015-07
Phase Phase 2
Genentech

332 total trials

What the finished NCT01442090 record still lists

NCT01442090 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (36% lower).

The record links to 0 conditions, and to 2 interventions - of which Everolimus is the first listed.

NCT01442090 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT01442090 about?

NCT01442090 is a clinical study titled "Study of GDC-0980 Versus Everolimus in Participants With Metastatic Renal Cell Carcinoma Who Have Progressed on or Following Vascular Endothelial Growth Factor- (VEGF) Targeted Therapy". Study PIM4973g is a multicenter, international, open-label Phase II trial. Participants with metastatic renal cell carcinoma who have progressed on or after VEGF targeted therapy will be randomized in 1:1 to two groups either to receive daily GDC-0980 or everolimus orally.

What is the current status of trial NCT01442090?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 85 participants. The study started on 2011-10. Estimated completion is 2015-07.

What interventions are being tested in trial NCT01442090?

The interventions under investigation include: Everolimus (DRUG), GDC-0980 (DRUG).

Who is sponsoring clinical trial NCT01442090?

This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT01442090's enrollment target sits among peer trials

85 820th of 2000 higher than 1,179 of 2,000 other Phase 2 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00842283 · 85 participants

    Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

  • NCT02133196 · 85 participants · Phase 2

    T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

  • NCT03823144 · 85 participants · NA

    Intravital Microscopy in Human Solid Tumors

  • NCT03875638 · 85 participants · Phase 2

    Treating Hyperexcitability in AD With Levetiracetam

Similar registry start date

  • NCT05988463 · started 2027-01-01 · Phase 1

    Dose-Escalation Study of Artesunate Patients With IPF

  • NCT07219706 · started 2026-12-10 · NA

    Dietary Fiber and Time Restricted Eating

  • NCT02831335 · started 2026-12-01

    Technical Development of Multi-Parametric Renocerebral MRI

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

Source: ClinicalTrials.gov NCT01442090, the US trial registry maintained by the National Library of Medicine. NCT01442090 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.