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NCT01431872 · ClinicalTrials.gov registry record
Systemic Dickkopf-related Protein 1 (DKK1)During Estrogen Level Changes in Post-menopausal Breast Cancer Patients Treated With Aromatase Inhibitors
A clinical trial, sponsored by University of Arkansas.
- Completed
- Registry status
- 17
- Enrollment target
NCT01431872: Completed study, sponsored by University of Arkansas.
NCT01431872 is a clinical trial that has completed, run by University of Arkansas. The registered enrollment target is 17 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01431872 has completed, sponsored by University of Arkansas.
- COMPLETED
- Registry status
- 17 participants
- Enrollment target
Study Summary
The investigators are hypothesizing that decreasing estrogen levels will cause serum DKK1 to peak, then decrease gradually as estrogens reach a new lower, but steady level. The investigators also believe that the peak in DKK1 will initiated a wave of stem cell diversion from the osteoblastogenic pathway to the adipogenic pathway. The investigators will conduct a longitudinal cohort study of post menopausal women with hormone-responsive breast cancer that will be treated AIs. The study will observe anthromorphic and serum marker changes during the first year of their treatment.
Primary Outcome
With the start of AI treatment, estrogen levels will decline to almost undetectable levels. We believe this decrease in estrogen will lift suppression of DKK1 and allow its expression to peak during the 1st month of treatment, and decline more slowly thereafter. During the first 26 weeks of treatment, we expect levels of CTx to rise, PTH to fall, and P1NP to show no change, findings that would be consistent with Heshmati's study.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2011-04 |
| Est. Completion | 2015-08 |
What the finished NCT01431872 record still lists
NCT01431872 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 17 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01431872 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01431872 about?
NCT01431872 is a clinical study titled "Systemic Dickkopf-related Protein 1 (DKK1)During Estrogen Level Changes in Post-menopausal Breast Cancer Patients Treated With Aromatase Inhibitors". The investigators are hypothesizing that decreasing estrogen levels will cause serum DKK1 to peak, then decrease gradually as estrogens reach a new lower, but steady level. The investigators also believe that the peak in DKK1 will initiated a wave of stem cell diversion from the osteoblastogenic pat...
What is the current status of trial NCT01431872?
This trial is currently completed. The enrollment target is 17 participants. The study started on 2011-04. Estimated completion is 2015-08.
Who is sponsoring clinical trial NCT01431872?
This trial is sponsored by University of Arkansas, which has 318 total clinical trials registered on ClinicalTrials.gov.
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