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NCT01428245 · ClinicalTrials.gov registry record · NA
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
A NA study, sponsored by University of Virginia.
- Terminated
- Registry status
- NA
- Development phase
- 3
- Enrollment target
NCT01428245: Clinical Trial NA study, sponsored by University of Virginia.
NCT01428245 is a NA study that was terminated before completion, run by University of Virginia. The registered enrollment target is 3 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01428245, a NA study, was terminated before completion, sponsored by University of Virginia.
- TERMINATED
- Registry status
- NA
- Development phase
- 3 participants
- Enrollment target
Study Summary
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH control the production of female hormones (such as estrogen and progesterone) and the development of eggs by the ovary. Progesterone and estrogen then decrease the number of GnRH pulses produced by the brain (and therefore the number of LH pulses from the pituitary). The ability to decrease GnRH pulses seems to be very important for normal menstrual function in adult women. The purpose of this study is to learn more about how GnRH and LH pulses are controlled during puberty. The information gathered in this study will hopefully allow us to learn more about how menstrual cycles are normally established in girls during puberty.
Primary Outcome
number of LH pulses per 11 hours on Day 7 of progesterone
Interventions
- DRUG Progesterone
- DRUG Estrace (estrogen)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2011-04-22 |
| Est. Completion | 2013-05-14 |
| Phase | NA |
Why NCT01428245 stopped before completion
NCT01428245 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which Progesterone is the first listed.
NCT01428245 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01428245 about?
NCT01428245 is a clinical study titled "Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition". Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH control the production of female hormones (such as estrogen and progesterone) and the development of egg...
What is the current status of trial NCT01428245?
This trial is currently terminated. It is a NA study. The enrollment target is 3 participants. The study started on 2011-04-22. Estimated completion is 2013-05-14.
What interventions are being tested in trial NCT01428245?
The interventions under investigation include: Progesterone (DRUG), Estrace (estrogen) (DRUG).
Who is sponsoring clinical trial NCT01428245?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01428245's enrollment target sits among peer trials
3 1996th of 2000 higher than 4 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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