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NCT01414608 · ClinicalTrials.gov registry record · Phase 3
Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer
A Phase 3 study, sponsored by GOG Foundation.
- Completed
- Registry status
- Phase 3
- Development phase
- 926
- Enrollment target
NCT01414608: Completed Phase 3 study, sponsored by GOG Foundation.
NCT01414608 is a Phase 3 study that has completed, run by GOG Foundation. The registered enrollment target is 926 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (20% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01414608, a Phase 3 study, has completed, sponsored by GOG Foundation.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 926 participants
- Enrollment target
Study Summary
This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with cervical cancer has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of \[cancer/tumor\] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.
Primary Outcome
Estimate for probability of overall survival at 5 years by Kaplan-Meier method, where overall survival is defined as the time from randomization to time of death due to any cause or the date of last contact, whichever occurs first.
Interventions
- DRUG Carboplatin
- DRUG Cisplatin
- RADIATION External Beam Radiation Therapy
- RADIATION Brachytherapy
- DRUG Paclitaxel
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 926 participants |
| Start Date | 2012-01-09 |
| Est. Completion | 2021-07-09 |
| Phase | Phase 3 |
What the finished NCT01414608 record still lists
NCT01414608 is an interventional study that assigns participants to a tested intervention. The registered 926 participants enrollment target is mid-sized for trials with a published cap, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (20% higher).
The record links to 0 conditions, and to 5 interventions - of which Carboplatin is the first listed.
NCT01414608 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01414608 about?
NCT01414608 is a clinical study titled "Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer". This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with cervical cancer has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as cisplatin,...
What is the current status of trial NCT01414608?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 926 participants. The study started on 2012-01-09. Estimated completion is 2021-07-09.
What interventions are being tested in trial NCT01414608?
The interventions under investigation include: Carboplatin (DRUG), Cisplatin (DRUG), External Beam Radiation Therapy (RADIATION), Brachytherapy (RADIATION), Paclitaxel (DRUG).
Who is sponsoring clinical trial NCT01414608?
This trial is sponsored by GOG Foundation, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01414608's enrollment target sits among peer trials
926 341st of 2000 higher than 1,660 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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