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NCT01409681 · ClinicalTrials.gov registry record
A Multi-Centered Trial Evaluating the Role of Vitamin D Metabolism in Non-Small Cell Lung Cancer
A clinical trial, sponsored by University of Michigan Rogel Cancer Center.
- Terminated
- Registry status
- 41
- Enrollment target
NCT01409681: Clinical Trial study, sponsored by University of Michigan Rogel Cancer Center.
NCT01409681 is a clinical trial that was terminated before completion, run by University of Michigan Rogel Cancer Center. The registered enrollment target is 41 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01409681 was terminated before completion, sponsored by University of Michigan Rogel Cancer Center.
- TERMINATED
- Registry status
- 41 participants
- Enrollment target
Study Summary
Vitamin D exerts antiproliferative and differentiating effects in cancers, including non-small cell lung cancer (NSCLC). The active form of Vitamin D is 1,25, dihydroxycholecalciferol (calcitriol) which rapidly induces expression of cytochrome P450 24R-hydroxylase (CYP24A1). CYP24A1 initiates inactivation of calcitriol as a result of successive hydroxylation/oxidation reactions. This study seeks to prospectively determine the relationship between Vitamin D gene expression and median survival as a primary outcome, and between the Vitamin D receptor (VDR)/CYP24A1 gene expression and cancer stage, smoking status, serum 1,25 (OH)2D3 levels as well as CYP24A1 genotype.
Primary Outcome
Time to lung cancer related death
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2011-05 |
| Est. Completion | 2013-12 |
Why NCT01409681 stopped before completion
NCT01409681 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 41 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01409681 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01409681 about?
NCT01409681 is a clinical study titled "A Multi-Centered Trial Evaluating the Role of Vitamin D Metabolism in Non-Small Cell Lung Cancer". Vitamin D exerts antiproliferative and differentiating effects in cancers, including non-small cell lung cancer (NSCLC). The active form of Vitamin D is 1,25, dihydroxycholecalciferol (calcitriol) which rapidly induces expression of cytochrome P450 24R-hydroxylase (CYP24A1). CYP24A1 initiates inacti...
What is the current status of trial NCT01409681?
This trial is currently terminated. The enrollment target is 41 participants. The study started on 2011-05. Estimated completion is 2013-12.
Who is sponsoring clinical trial NCT01409681?
This trial is sponsored by University of Michigan Rogel Cancer Center, which has 292 total clinical trials registered on ClinicalTrials.gov.
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